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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Gastrointest+Oncol
2014 ; 5
(3
): 236-46
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The tolerance of gastrointestinal organs to stereotactic body radiation therapy:
what do we know so far?
#MMPMID24982772
Thomas TO
; Hasan S
; Small W Jr
; Herman JM
; Lock M
; Kim EY
; Mayr NA
; Teh BS
; Lo SS
J Gastrointest Oncol
2014[Jun]; 5
(3
): 236-46
PMID24982772
show ga
As stereotactic body radiation therapy (SBRT) for gastrointestinal (GI) gains
popularity, there is a need to optimize doses and fractionation to minimize GI
toxicity. GI organs that have classically developed radiation-induced toxicity
include the liver & biliary system, small bowel, esophagus, and rectum. While the
literature quantifies dose restrictions for these organs under standard
fractionation, there is limited data regarding toxicity with the ablative dose
schedules used in SBRT. We conducted a review of the literature to identify
prospective and retrospective studies that detail GI toxicities when SBRT was
employed. Based on the literature, the median SBRT dose for abdominal and
thoracic tumors ranged from 24 to 60 Gy, at 5 to 25 Gy per fraction. The
respective observed frequencies of grade 3 and 4 toxicities for the liver,
biliary system, small bowel, and esophagus were variable among different studies.
Typically, patients who suffered grade 3 and 4 toxicities were more likely to
have had some form of systemic therapy as well. The effect of dose,
fractionation, timing, and volume on GI toxicities has been described in the
literature but more data is necessary to develop uniform treatment guidelines for
SBRT.