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10.1016/j.jpeds.2014.02.065

http://scihub22266oqcxt.onion/10.1016/j.jpeds.2014.02.065
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C4074567!4074567 !24721467
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suck abstract from ncbi

pmid24721467
      J+Pediatr 2014 ; 165 (1 ): 194-6
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  • A single misstep in cardiac development explains the co-occurrence of tetralogy of fallot and complete atrioventricular septal defect in Down syndrome #MMPMID24721467
  • Nguyen HH ; Jay PY
  • J Pediatr 2014[Jul]; 165 (1 ): 194-6 PMID24721467 show ga
  • Tetralogy of Fallot and a complete atrioventricular septal defect are thought to arise by distinct mechanisms, yet their co-occurrence is a recognized association. Analysis of the prevalence of co-occurrence in Down syndrome suggests a common developmental basis. Trisomy 21 may perturb cardiac progenitor cells before they enter the heart tube.
  • |Child, Preschool [MESH]
  • |Down Syndrome/*complications/physiopathology [MESH]
  • |Heart Septal Defects [MESH]
  • |Humans [MESH]
  • |Infant [MESH]
  • |Mitral Valve Insufficiency/*complications/epidemiology/physiopathology [MESH]


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