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10.1016/j.ccr.2014.04.016 http://scihub22266oqcxt.onion/10.1016/j.ccr.2014.04.016 C4074519!4074519!24882515     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cancer+Cell 2014 ; 25 (6): 831-45 Nephropedia Template TP {{tp|p=24882515|t=2014. Hippo-Independent Activation of YAP by the GNAQ Uveal Melanoma Oncogene through a Trio-regulated Rho GTPase Signaling Circuitry |pdf=|usr=}}{{24882515}} gab.com Text Hippo-Independent Activation of YAP by the GNAQ Uveal Melanoma Oncogene through a Trio-regulated Rho GTPase Signaling Circuitry JO: Cancer Cell http://www.kidney.de/pget.php?&tw=1&pmid=24882515 #FOAvip Mutually exclusive activating mutations in the GNAQ and GNA11 oncogenes, encoding heterotrimeric G?q family members, have been identified in ~83% and ~6% of uveal and skin melanomas, respectively. However, the molecular events underlying these GNAQ-driven malignancies are not yet defined, thus limiting the ability to develop cancer-targeted therapies. Here, we focused on the transcriptional co-activator YAP, a critical component of the Hippo signaling pathway that controls organ size. We found that G?q stimulates YAP through a Trio-Rho/Rac signaling circuitry promoting actin polymerization, independently of PLC? and the canonical Hippo pathway. Furthermore, we show that G?q promotes the YAP-dependent growth of uveal melanoma cells, thereby identifying YAP as a suitable therapeutic target in uveal melanoma, the first described GNAQ/GNA11-initiated human malignancy. Twit Text FOAVip Hippo-Independent Activation of YAP by the GNAQ Uveal Melanoma Oncogene through a Trio-regulated Rho GTPase Signaling Circuitry ????Cancer Cell http://www.kidney.de/pget.php?&tw=1&pmid=24882515 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24882515 #FOAvip English Wikipedia <ref>{{Cite pmid|24882515}}</ref> Hippo-Independent Activation of YAP by the GNAQ Uveal Melanoma Oncogene through a Trio-regulated Rho GTPase Signaling Circuitry #MMPMID24882515 Feng X; Degese MS; Iglesias-Bartolome R; Vaque JP; Molinolo AA; Rodrigues M; Zaidi MR; Ksander BR; Merlino G; Sodhi A; Chen Q; Gutkind JS Cancer Cell 2014[Jun]; 25 (6): 831-45 PMID24882515show ga Mutually exclusive activating mutations in the GNAQ and GNA11 oncogenes, encoding heterotrimeric G?q family members, have been identified in ~83% and ~6% of uveal and skin melanomas, respectively. However, the molecular events underlying these GNAQ-driven malignancies are not yet defined, thus limiting the ability to develop cancer-targeted therapies. Here, we focused on the transcriptional co-activator YAP, a critical component of the Hippo signaling pathway that controls organ size. We found that G?q stimulates YAP through a Trio-Rho/Rac signaling circuitry promoting actin polymerization, independently of PLC? and the canonical Hippo pathway. Furthermore, we show that G?q promotes the YAP-dependent growth of uveal melanoma cells, thereby identifying YAP as a suitable therapeutic target in uveal melanoma, the first described GNAQ/GNA11-initiated human malignancy. äHippo-Independent Activation of YAP by the GNAQ Uveal Melanoma Oncogen(epmc).pdf DeepDyve Pubget Overpricing