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10.1016/j.ccr.2014.04.016 http://scihub22266oqcxt.onion/10.1016/j.ccr.2014.04.016 C4074519!4074519 !24882515     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24882515 &cmd=llinks): Failed to open stream: HTTP request failed! 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Hippo-independent activation of YAP by the GNAQ uveal melanoma oncogene through a trio-regulated rho GTPase signaling circuitry |pdf=|usr=}}{{24882515 }} gab.com Text Hippo-independent activation of YAP by the GNAQ uveal melanoma oncogene through a trio-regulated rho GTPase signaling circuitry JO: Cancer Cell http://www.kidney.de/pget.php?&tw=1&pmid=24882515 #FOAvip Mutually exclusive activating mutations in the GNAQ and GNA11 oncogenes, encoding heterotrimeric G?q family members, have been identified in ? 83% and ? 6% of uveal and skin melanomas, respectively. However, the molecular events underlying these GNAQ-driven malignancies are not yet defined, thus limiting the ability to develop cancer-targeted therapies. Here, we focused on the transcriptional coactivator YAP, a critical component of the Hippo signaling pathway that controls organ size. We found that G?q stimulates YAP through a Trio-Rho/Rac signaling circuitry promoting actin polymerization, independently of phospholipase C? and the canonical Hippo pathway. Furthermore, we show that G?q promotes the YAP-dependent growth of uveal melanoma cells, thereby identifying YAP as a suitable therapeutic target in uveal melanoma, a GNAQ/GNA11-initiated human malignancy. Twit Text FOAVip Hippo-independent activation of YAP by the GNAQ uveal melanoma oncogene through a trio-regulated rho GTPase signaling circuitry ????Cancer Cell http://www.kidney.de/pget.php?&tw=1&pmid=24882515 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24882515 #FOAvip English Wikipedia <ref>{{Cite pmid|24882515 }}</ref> Hippo-independent activation of YAP by the GNAQ uveal melanoma oncogene through a trio-regulated rho GTPase signaling circuitry #MMPMID24882515 Feng X ; Degese MS ; Iglesias-Bartolome R ; Vaque JP ; Molinolo AA ; Rodrigues M ; Zaidi MR ; Ksander BR ; Merlino G ; Sodhi A ; Chen Q ; Gutkind JS Cancer Cell 2014[Jun]; 25 (6 ): 831-45 PMID24882515 show ga Mutually exclusive activating mutations in the GNAQ and GNA11 oncogenes, encoding heterotrimeric G?q family members, have been identified in ? 83% and ? 6% of uveal and skin melanomas, respectively. However, the molecular events underlying these GNAQ-driven malignancies are not yet defined, thus limiting the ability to develop cancer-targeted therapies. Here, we focused on the transcriptional coactivator YAP, a critical component of the Hippo signaling pathway that controls organ size. We found that G?q stimulates YAP through a Trio-Rho/Rac signaling circuitry promoting actin polymerization, independently of phospholipase C? and the canonical Hippo pathway. Furthermore, we show that G?q promotes the YAP-dependent growth of uveal melanoma cells, thereby identifying YAP as a suitable therapeutic target in uveal melanoma, a GNAQ/GNA11-initiated human malignancy. |Animals [MESH] |Cell Cycle Proteins [MESH] |Cell Growth Processes/physiology [MESH] |Cell Line, Tumor [MESH] |Female [MESH] |GTP Phosphohydrolases/genetics/*metabolism [MESH] |GTP-Binding Protein alpha Subunits, Gq-G11 [MESH] |GTP-Binding Protein alpha Subunits/*genetics/metabolism [MESH] |Gene Knockdown Techniques [MESH] |HEK293 Cells [MESH] |Heterografts [MESH] |Hippo Signaling Pathway [MESH] |Humans [MESH] |Melanoma, Cutaneous Malignant [MESH] |Melanoma/enzymology/*genetics/metabolism [MESH] |Mice [MESH] |Mice, Inbred NOD [MESH] |Mutation [MESH] |Nuclear Proteins/*genetics/metabolism [MESH] |Protein Serine-Threonine Kinases/genetics/*metabolism [MESH] |Signal Transduction [MESH] |Skin Neoplasms [MESH] |Transcription Factors/*genetics/metabolism [MESH] |Transfection [MESH] |Uveal Melanoma [MESH] |Uveal Neoplasms/enzymology/*genetics/metabolism [MESH]Hippo-independent activation of YAP by the GNAQ uveal melanoma oncogen(epmc).pdf DeepDyve Pubget Overpricing