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10.1242/dev.099986 http://scihub22266oqcxt.onion/10.1242/dev.099986 C4074308!4074308!24598161     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Development 2014 ; 141 (7): 1544-52 Nephropedia Template TP {{tp|p=24598161|t=2014. Distinct Notch signaling outputs pattern the developing arterial system |pdf=|usr=}}{{24598161}} gab.com Text Distinct Notch signaling outputs pattern the developing arterial system JO: Development http://www.kidney.de/pget.php?&tw=1&pmid=24598161 #FOAvip Differentiation of arteries and veins is essential for the development of a functional circulatory system. In vertebrate embryos, genetic manipulation of Notch signaling has demonstrated the importance of this pathway in driving artery endothelial cell differentiation. However, when and where Notch activation occurs to affect endothelial cell fate is less clear. Using transgenic zebrafish bearing a Notch-responsive reporter, we demonstrate that Notch is activated in endothelial progenitors during vasculogenesis prior to blood vessel morphogenesis and is maintained in arterial endothelial cells throughout larval stages. Furthermore, we find that endothelial progenitors in which Notch is activated are committed to a dorsal aorta fate. Interestingly, some arterial endothelial cells subsequently downregulate Notch signaling and then contribute to veins during vascular remodeling. Lineage analysis, together with perturbation of both Notch receptor and ligand function, further suggests several distinct developmental windows in which Notch signaling acts to promote artery commitment and maintenance. Together, these findings demonstrate that Notch acts in distinct contexts to initiate and maintain artery identity during embryogenesis. Twit Text FOAVip Distinct Notch signaling outputs pattern the developing arterial system ????Development http://www.kidney.de/pget.php?&tw=1&pmid=24598161 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24598161 #FOAvip English Wikipedia <ref>{{Cite pmid|24598161}}</ref> Distinct Notch signaling outputs pattern the developing arterial system #MMPMID24598161 Quillien A; Moore JC; Shin M; Siekmann AF; Smith T; Pan L; Moens CB; Parsons MJ; Lawson ND Development 2014[Apr]; 141 (7): 1544-52 PMID24598161show ga Differentiation of arteries and veins is essential for the development of a functional circulatory system. In vertebrate embryos, genetic manipulation of Notch signaling has demonstrated the importance of this pathway in driving artery endothelial cell differentiation. However, when and where Notch activation occurs to affect endothelial cell fate is less clear. Using transgenic zebrafish bearing a Notch-responsive reporter, we demonstrate that Notch is activated in endothelial progenitors during vasculogenesis prior to blood vessel morphogenesis and is maintained in arterial endothelial cells throughout larval stages. Furthermore, we find that endothelial progenitors in which Notch is activated are committed to a dorsal aorta fate. Interestingly, some arterial endothelial cells subsequently downregulate Notch signaling and then contribute to veins during vascular remodeling. Lineage analysis, together with perturbation of both Notch receptor and ligand function, further suggests several distinct developmental windows in which Notch signaling acts to promote artery commitment and maintenance. Together, these findings demonstrate that Notch acts in distinct contexts to initiate and maintain artery identity during embryogenesis. äDistinct Notch signaling outputs pattern the developing arterial syste(epmc).pdf DeepDyve Pubget Overpricing