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10.1007/s00213-014-3436-2 http://scihub22266oqcxt.onion/10.1007/s00213-014-3436-2 C4074245!4074245!24481567     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Psychopharmacology+(Berl) 2014 ; 231 (14): 2751-8 Nephropedia Template TP {{tp|p=24481567|t=2014. ASSESSMENT OF THE KAPPA OPIOID AGONIST, SALVINORIN A, AS A PUNISHER OF DRUG SELF-ADMINISTRATION IN MONKEYS |pdf=|usr=}}{{24481567}} gab.com Text ASSESSMENT OF THE KAPPA OPIOID AGONIST, SALVINORIN A, AS A PUNISHER OF DRUG SELF-ADMINISTRATION IN MONKEYS JO: Psychopharmacology (Berl) http://www.kidney.de/pget.php?&tw=1&pmid=24481567 #FOAvip Rationale: Drugs can function as punishers. However, work on the study of drugs as punishers is limited, as are the range of compounds known to function as punishers. Kappa opioid agonists, which have received much experimental attention as potential therapeutics for drug abuse, reportedly produce aversive effects. However, kappa agonists have yet to be tested as punishers of behavior. Objective: The goal of the current study was to determine if a kappa agonist could function as a punisher of drug self-administration. Method: In separate experiments, monkeys were allowed to choose in a two-lever choice design between intravenous injections of equal doses of either cocaine (0.1 mg/kg/inj on each lever) or remifentanil (0.1 ?g/kg/inj on each lever) when one of the two options was mixed with various doses of the kappa agonist, salvinorin A. Results: Choice for the cocaine and remifentanil options that were combined with salvinorin A decreased as a function of salvinorin A dose in all monkeys. However, operant response rates were not systematically affected by salvinorin A administration. Conclusion: The present findings demonstrate that the kappa agonist, salvinorin A, can punish self-administration of a mu opioid, remifentanil, and a psychostimulant, cocaine. In consideration of these findings, it may be possible to curtail the abuse of some drugs by contingently delivering kappa agonists (e.g., as combination formularies for prescription medications). Twit Text FOAVip ASSESSMENT OF THE KAPPA OPIOID AGONIST, SALVINORIN A, AS A PUNISHER OF DRUG SELF-ADMINISTRATION IN MONKEYS ????Psychopharmacology (Berl) http://www.kidney.de/pget.php?&tw=1&pmid=24481567 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24481567 #FOAvip English Wikipedia <ref>{{Cite pmid|24481567}}</ref> ASSESSMENT OF THE KAPPA OPIOID AGONIST, SALVINORIN A, AS A PUNISHER OF DRUG SELF-ADMINISTRATION IN MONKEYS #MMPMID24481567 Freeman KB; Naylor JE; Prisinzano TE; Woolverton WL Psychopharmacology (Berl) 2014[Jul]; 231 (14): 2751-8 PMID24481567show ga Rationale: Drugs can function as punishers. However, work on the study of drugs as punishers is limited, as are the range of compounds known to function as punishers. Kappa opioid agonists, which have received much experimental attention as potential therapeutics for drug abuse, reportedly produce aversive effects. However, kappa agonists have yet to be tested as punishers of behavior. Objective: The goal of the current study was to determine if a kappa agonist could function as a punisher of drug self-administration. Method: In separate experiments, monkeys were allowed to choose in a two-lever choice design between intravenous injections of equal doses of either cocaine (0.1 mg/kg/inj on each lever) or remifentanil (0.1 ?g/kg/inj on each lever) when one of the two options was mixed with various doses of the kappa agonist, salvinorin A. Results: Choice for the cocaine and remifentanil options that were combined with salvinorin A decreased as a function of salvinorin A dose in all monkeys. However, operant response rates were not systematically affected by salvinorin A administration. Conclusion: The present findings demonstrate that the kappa agonist, salvinorin A, can punish self-administration of a mu opioid, remifentanil, and a psychostimulant, cocaine. In consideration of these findings, it may be possible to curtail the abuse of some drugs by contingently delivering kappa agonists (e.g., as combination formularies for prescription medications). äASSESSMENT OF THE KAPPA OPIOID AGONIST, SALVINORIN A, AS A PUNISHER OF(epmc).pdf DeepDyve Pubget Overpricing