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10.1111/nyas.12458

http://scihub22266oqcxt.onion/10.1111/nyas.12458
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C4074217!4074217!24840700
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suck abstract from ncbi

pmid24840700      Ann+N+Y+Acad+Sci 2014 ; 1319 (1): 82-95
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  • Mechanism of NLRP3 inflammasome activation #MMPMID24840700
  • Sutterwala FS; Haasken S; Cassel SL
  • Ann N Y Acad Sci 2014[Jun]; 1319 (1): 82-95 PMID24840700show ga
  • Inflammasomes continue to generate interest in an increasing number of disciplines owing to their unique ability to integrate a myriad of signals from pathogen- and damage-associated molecular patterns into a proinflammatory response. This potent caspase-1?dependent process is capable of activating the innate immune system, initiating pyroptosis (an inflammatory form of programmed cell death), and shaping adaptive immunity. The NLRP3 inflammasome is the most thoroughly studied of the inflammasome complexes that have been described thus far, perhaps owing to its disparate assortment of agonists. This review will highlight our current understanding of the mechanisms of both priming and activation of the NLRP3 inflammasome.
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