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http://scihub22266oqcxt.onion/ C4073693!4073693!20840072     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Curr+Drug+Targets 2010 ; 11 (10): 1296-303 Nephropedia Template TP {{tp|p=20840072|t=2010. The Mutator Phenotype in Cancer: Molecular Mechanisms and Targeting Strategies |pdf=|usr=}}{{20840072}} gab.com Text The Mutator Phenotype in Cancer: Molecular Mechanisms and Targeting Strategies JO: Curr Drug Targets http://www.kidney.de/pget.php?&tw=1&pmid=20840072 #FOAvip Normal human cells replicate their DNA with exceptional accuracy. It has been estimated that approximately one error occurs during DNA replication for each 109 to 1010 nucleotides polymerized. In contrast, malignant cells exhibit multiple chromosomal abnormalities and contain tens of thousands of alterations in the nucleotide sequence of nuclear DNA. To account for the disparity between the rarity of mutations in normal cells and the large numbers of mutations present in cancer, we have hypothesized that during tumor development, cancer cells exhibit a mutator phenotype. As a defining feature of cancer, the mutator phenotype remains an as-yet unexplored therapeutic target: by reducing the rate at which mutations accumulate it may be possible to significantly delay tumor development; conversely, the large number of mutations in cancer may make cancer cells more sensitive to cell killing by increasing the mutation rate. Here we summarize the evidence for the mutator phenotype hypothesis in cancer and explore how the increased frequency of random mutations during the evolution of human tumors provides new approaches for the design of cancer chemotherapy. Twit Text FOAVip The Mutator Phenotype in Cancer: Molecular Mechanisms and Targeting Strategies ????Curr Drug Targets http://www.kidney.de/pget.php?&tw=1&pmid=20840072 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=20840072 #FOAvip English Wikipedia <ref>{{Cite pmid|20840072}}</ref> The Mutator Phenotype in Cancer: Molecular Mechanisms and Targeting Strategies #MMPMID20840072 Prindle MJ; Fox EJ; Loeb LA Curr Drug Targets 2010[Oct]; 11 (10): 1296-303 PMID20840072show ga Normal human cells replicate their DNA with exceptional accuracy. It has been estimated that approximately one error occurs during DNA replication for each 109 to 1010 nucleotides polymerized. In contrast, malignant cells exhibit multiple chromosomal abnormalities and contain tens of thousands of alterations in the nucleotide sequence of nuclear DNA. To account for the disparity between the rarity of mutations in normal cells and the large numbers of mutations present in cancer, we have hypothesized that during tumor development, cancer cells exhibit a mutator phenotype. As a defining feature of cancer, the mutator phenotype remains an as-yet unexplored therapeutic target: by reducing the rate at which mutations accumulate it may be possible to significantly delay tumor development; conversely, the large number of mutations in cancer may make cancer cells more sensitive to cell killing by increasing the mutation rate. Here we summarize the evidence for the mutator phenotype hypothesis in cancer and explore how the increased frequency of random mutations during the evolution of human tumors provides new approaches for the design of cancer chemotherapy. äThe Mutator Phenotype in Cancer: Molecular Mechanisms and Targeting St(epmc).pdf DeepDyve Pubget Overpricing