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10.1681/ASN.2013080837 http://scihub22266oqcxt.onion/10.1681/ASN.2013080837 C4073434!4073434!24610932     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Am+Soc+Nephrol 2014 ; 25 (7): 1575-85 Nephropedia Template TP {{tp|p=24610932|t=2014. Immunologic Human Renal Allograft Injury Associates with an Altered IL-10/TNF-? Expression Ratio in Regulatory B Cells |pdf=|usr=}}{{24610932}} gab.com Text Immunologic Human Renal Allograft Injury Associates with an Altered IL-10/TNF- Expression Ratio in Regulatory B Cells JO: J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=24610932 #FOAvip Human B cells with immunoregulatory properties in vitro (Bregs) have been defined by the expression of IL-10 and are enriched in various B-cell subsets. However, proinflammatory cytokine expression in B-cell subsets is largely unexplored. We examined the cytokine profiles of human PBMCs and found that subsets of CD24hiCD38hi transitional B cells (TrBs), CD24hiCD27+ memory B cells, and naïve B cells express IL-10 and the proinflammatory cytokine TNF-? simultaneously. TrBs had the highest IL-10/TNF-? ratio and suppressed proinflammatory helper T cell 1 (Th1) cytokine expression by autologous T cells in vitro more potently than memory B cells did, despite similar IL-10 expression. Whereas neutralization of IL-10 significantly inhibited TrB-mediated suppression of autologous Th1 cytokine expression, blocking TNF-? increased the suppressive capacity of both memory and naïve B-cell subsets. Thus, the ratio of IL-10/TNF-? expression, a measure of cytokine polarization, may be a better indicator of regulatory function than IL-10 expression alone. Indeed, compared with TrB cells from patients with stable kidney graft function, TrBs from patients with graft rejection displayed similar IL-10 expression levels but increased TNF-? expression (i.e., reduced IL-10/TNF-? ratio), did not inhibit in vitro expression of Th1 cytokines by T cells, and abnormally suppressed expression of Th2 cytokines. In patients with graft dysfunction, a low IL-10/TNF-? ratio in TrBs associated with poor graft outcomes after 3 years of follow-up. In summary, these results indicate that B cell?mediated immune regulation is best characterized by the cytokine polarization profile, a finding that was confirmed in renal transplant patients. Twit Text FOAVip Immunologic Human Renal Allograft Injury Associates with an Altered IL-10/TNF- Expression Ratio in Regulatory B Cells ????J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=24610932 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24610932 #FOAvip English Wikipedia <ref>{{Cite pmid|24610932}}</ref> Immunologic Human Renal Allograft Injury Associates with an Altered IL-10/TNF-? Expression Ratio in Regulatory B Cells #MMPMID24610932 Cherukuri A; Rothstein DM; Clark B; Carter CR; Davison A; Hernandez-Fuentes M; Hewitt E; Salama AD; Baker RJ J Am Soc Nephrol 2014[Jul]; 25 (7): 1575-85 PMID24610932show ga Human B cells with immunoregulatory properties in vitro (Bregs) have been defined by the expression of IL-10 and are enriched in various B-cell subsets. However, proinflammatory cytokine expression in B-cell subsets is largely unexplored. We examined the cytokine profiles of human PBMCs and found that subsets of CD24hiCD38hi transitional B cells (TrBs), CD24hiCD27+ memory B cells, and naïve B cells express IL-10 and the proinflammatory cytokine TNF-? simultaneously. TrBs had the highest IL-10/TNF-? ratio and suppressed proinflammatory helper T cell 1 (Th1) cytokine expression by autologous T cells in vitro more potently than memory B cells did, despite similar IL-10 expression. Whereas neutralization of IL-10 significantly inhibited TrB-mediated suppression of autologous Th1 cytokine expression, blocking TNF-? increased the suppressive capacity of both memory and naïve B-cell subsets. Thus, the ratio of IL-10/TNF-? expression, a measure of cytokine polarization, may be a better indicator of regulatory function than IL-10 expression alone. Indeed, compared with TrB cells from patients with stable kidney graft function, TrBs from patients with graft rejection displayed similar IL-10 expression levels but increased TNF-? expression (i.e., reduced IL-10/TNF-? ratio), did not inhibit in vitro expression of Th1 cytokines by T cells, and abnormally suppressed expression of Th2 cytokines. In patients with graft dysfunction, a low IL-10/TNF-? ratio in TrBs associated with poor graft outcomes after 3 years of follow-up. In summary, these results indicate that B cell?mediated immune regulation is best characterized by the cytokine polarization profile, a finding that was confirmed in renal transplant patients. äImmunologic Human Renal Allograft Injury Associates with an Altered IL(epmc).pdf DeepDyve Pubget Overpricing