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10.1681/ASN.2013080837 http://scihub22266oqcxt.onion/10.1681/ASN.2013080837 C4073434!4073434 !24610932     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24610932 &cmd=llinks): Failed to open stream: HTTP request failed! 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Immunologic human renal allograft injury associates with an altered IL-10/TNF-? expression ratio in regulatory B cells |pdf=|usr=}}{{24610932 }} gab.com Text Immunologic human renal allograft injury associates with an altered IL-10/TNF- expression ratio in regulatory B cells JO: J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=24610932 #FOAvip Human B cells with immunoregulatory properties in vitro (Bregs) have been defined by the expression of IL-10 and are enriched in various B-cell subsets. However, proinflammatory cytokine expression in B-cell subsets is largely unexplored. We examined the cytokine profiles of human PBMCs and found that subsets of CD24(hi)CD38(hi) transitional B cells (TrBs), CD24(hi)CD27(+) memory B cells, and naïve B cells express IL-10 and the proinflammatory cytokine TNF-? simultaneously. TrBs had the highest IL-10/TNF-? ratio and suppressed proinflammatory helper T cell 1 (Th1) cytokine expression by autologous T cells in vitro more potently than memory B cells did, despite similar IL-10 expression. Whereas neutralization of IL-10 significantly inhibited TrB-mediated suppression of autologous Th1 cytokine expression, blocking TNF-? increased the suppressive capacity of both memory and naïve B-cell subsets. Thus, the ratio of IL-10/TNF-? expression, a measure of cytokine polarization, may be a better indicator of regulatory function than IL-10 expression alone. Indeed, compared with TrB cells from patients with stable kidney graft function, TrBs from patients with graft rejection displayed similar IL-10 expression levels but increased TNF-? expression (i.e., reduced IL-10/TNF-? ratio), did not inhibit in vitro expression of Th1 cytokines by T cells, and abnormally suppressed expression of Th2 cytokines. In patients with graft dysfunction, a low IL-10/TNF-? ratio in TrBs associated with poor graft outcomes after 3 years of follow-up. In summary, these results indicate that B cell-mediated immune regulation is best characterized by the cytokine polarization profile, a finding that was confirmed in renal transplant patients. Twit Text FOAVip Immunologic human renal allograft injury associates with an altered IL-10/TNF- expression ratio in regulatory B cells ????J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=24610932 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24610932 #FOAvip English Wikipedia <ref>{{Cite pmid|24610932 }}</ref> Immunologic human renal allograft injury associates with an altered IL-10/TNF-? expression ratio in regulatory B cells #MMPMID24610932 Cherukuri A ; Rothstein DM ; Clark B ; Carter CR ; Davison A ; Hernandez-Fuentes M ; Hewitt E ; Salama AD ; Baker RJ J Am Soc Nephrol 2014[Jul]; 25 (7 ): 1575-85 PMID24610932 show ga Human B cells with immunoregulatory properties in vitro (Bregs) have been defined by the expression of IL-10 and are enriched in various B-cell subsets. However, proinflammatory cytokine expression in B-cell subsets is largely unexplored. We examined the cytokine profiles of human PBMCs and found that subsets of CD24(hi)CD38(hi) transitional B cells (TrBs), CD24(hi)CD27(+) memory B cells, and naïve B cells express IL-10 and the proinflammatory cytokine TNF-? simultaneously. TrBs had the highest IL-10/TNF-? ratio and suppressed proinflammatory helper T cell 1 (Th1) cytokine expression by autologous T cells in vitro more potently than memory B cells did, despite similar IL-10 expression. Whereas neutralization of IL-10 significantly inhibited TrB-mediated suppression of autologous Th1 cytokine expression, blocking TNF-? increased the suppressive capacity of both memory and naïve B-cell subsets. Thus, the ratio of IL-10/TNF-? expression, a measure of cytokine polarization, may be a better indicator of regulatory function than IL-10 expression alone. Indeed, compared with TrB cells from patients with stable kidney graft function, TrBs from patients with graft rejection displayed similar IL-10 expression levels but increased TNF-? expression (i.e., reduced IL-10/TNF-? ratio), did not inhibit in vitro expression of Th1 cytokines by T cells, and abnormally suppressed expression of Th2 cytokines. In patients with graft dysfunction, a low IL-10/TNF-? ratio in TrBs associated with poor graft outcomes after 3 years of follow-up. In summary, these results indicate that B cell-mediated immune regulation is best characterized by the cytokine polarization profile, a finding that was confirmed in renal transplant patients. |Adult [MESH] |B-Lymphocytes, Regulatory/*immunology/metabolism [MESH] |Female [MESH] |Graft Rejection/immunology [MESH] |Humans [MESH] |Interleukin-10/biosynthesis/*immunology [MESH] |Kidney Neoplasms/*immunology [MESH] |Male [MESH] |Middle Aged [MESH] |Postoperative Complications/immunology [MESH] |Retrospective Studies [MESH]Immunologic human renal allograft injury associates with an altered IL(epmc).pdf DeepDyve Pubget Overpricing