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10.1681/ASN.2013070679 http://scihub22266oqcxt.onion/10.1681/ASN.2013070679 C4073429!4073429!24511123     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Am+Soc+Nephrol 2014 ; 25 (7): 1474-85 Nephropedia Template TP {{tp|p=24511123|t=2014. Epac-Rap Signaling Reduces Oxidative Stress in the Tubular Epithelium |pdf=|usr=}}{{24511123}} gab.com Text Epac-Rap Signaling Reduces Oxidative Stress in the Tubular Epithelium JO: J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=24511123 #FOAvip Activation of Rap1 by exchange protein activated by cAMP (Epac) promotes cell adhesion and actin cytoskeletal polarization. Pharmacologic activation of Epac-Rap signaling by the Epac-selective cAMP analog 8-pCPT-2?-O-Me-cAMP during ischemia-reperfusion (IR) injury reduces renal failure and application of 8-pCPT-2?-O-Me-cAMP promotes renal cell survival during exposure to the nephrotoxicant cisplatin. Here, we found that activation of Epac by 8-pCPT-2?-O-Me-cAMP reduced production of reactive oxygen species during reoxygenation after hypoxia by decreasing mitochondrial superoxide production. Epac activation prevented disruption of tubular morphology during diethyl maleate?induced oxidative stress in an organotypic three-dimensional culture assay. In vivo renal targeting of 8-pCPT-2?-O-Me-cAMP to proximal tubules using a kidney-selective drug carrier approach resulted in prolonged activation of Rap1 compared with nonconjugated 8-pCPT-2?-O-Me-cAMP. Activation of Epac reduced antioxidant signaling during IR injury and prevented tubular epithelial injury, apoptosis, and renal failure. Our data suggest that Epac1 decreases reactive oxygen species production by preventing mitochondrial superoxide formation during IR injury, thus limiting the degree of oxidative stress. These findings indicate a new role for activation of Epac as a therapeutic application in renal injury associated with oxidative stress. Twit Text FOAVip Epac-Rap Signaling Reduces Oxidative Stress in the Tubular Epithelium ????J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=24511123 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24511123 #FOAvip English Wikipedia <ref>{{Cite pmid|24511123}}</ref> Epac-Rap Signaling Reduces Oxidative Stress in the Tubular Epithelium #MMPMID24511123 Stokman G; Qin Y; Booij TH; Ramaiahgari S; Lacombe M; Dolman MEM; van Dorenmalen KM; Teske GJ; Florquin S; Schwede F; van de Water B; Kok RJ; Price LS J Am Soc Nephrol 2014[Jul]; 25 (7): 1474-85 PMID24511123show ga Activation of Rap1 by exchange protein activated by cAMP (Epac) promotes cell adhesion and actin cytoskeletal polarization. Pharmacologic activation of Epac-Rap signaling by the Epac-selective cAMP analog 8-pCPT-2?-O-Me-cAMP during ischemia-reperfusion (IR) injury reduces renal failure and application of 8-pCPT-2?-O-Me-cAMP promotes renal cell survival during exposure to the nephrotoxicant cisplatin. Here, we found that activation of Epac by 8-pCPT-2?-O-Me-cAMP reduced production of reactive oxygen species during reoxygenation after hypoxia by decreasing mitochondrial superoxide production. Epac activation prevented disruption of tubular morphology during diethyl maleate?induced oxidative stress in an organotypic three-dimensional culture assay. In vivo renal targeting of 8-pCPT-2?-O-Me-cAMP to proximal tubules using a kidney-selective drug carrier approach resulted in prolonged activation of Rap1 compared with nonconjugated 8-pCPT-2?-O-Me-cAMP. Activation of Epac reduced antioxidant signaling during IR injury and prevented tubular epithelial injury, apoptosis, and renal failure. Our data suggest that Epac1 decreases reactive oxygen species production by preventing mitochondrial superoxide formation during IR injury, thus limiting the degree of oxidative stress. These findings indicate a new role for activation of Epac as a therapeutic application in renal injury associated with oxidative stress. äEpac-Rap Signaling Reduces Oxidative Stress in the Tubular Epithelium (epmc).pdf DeepDyve Pubget Overpricing