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10.1681/ASN.2013060641 http://scihub22266oqcxt.onion/10.1681/ASN.2013060641 C4073428!4073428!24652800     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Am+Soc+Nephrol 2014 ; 25 (7): 1430-9 Nephropedia Template TP {{tp|p=24652800|t=2014. Local Renal Circadian Clocks Control Fluid?Electrolyte Homeostasis and BP |pdf=|usr=}}{{24652800}} gab.com Text Local Renal Circadian Clocks Control Fluid Electrolyte Homeostasis and BP JO: J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=24652800 #FOAvip The circadian timing system is critically involved in the maintenance of fluid and electrolyte balance and BP control. However, the role of peripheral circadian clocks in these homeostatic mechanisms remains unknown. We addressed this question in a mouse model carrying a conditional allele of the circadian clock gene Bmal1 and expressing Cre recombinase under the endogenous Renin promoter (Bmal1lox/lox/Ren1dCre mice). Analysis of Bmal1lox/lox/Ren1dCre mice showed that the floxed Bmal1 allele was excised in the kidney. In the kidney, BMAL1 protein expression was absent in the renin-secreting granular cells of the juxtaglomerular apparatus and the collecting duct. A partial reduction of BMAL1 expression was observed in the medullary thick ascending limb. Functional analyses showed that Bmal1lox/lox/Ren1dCre mice exhibited multiple abnormalities, including increased urine volume, changes in the circadian rhythm of urinary sodium excretion, increased GFR, and significantly reduced plasma aldosterone levels. These changes were accompanied by a reduction in BP. These results show that local renal circadian clocks control body fluid and BP homeostasis. Twit Text FOAVip Local Renal Circadian Clocks Control Fluid Electrolyte Homeostasis and BP ????J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=24652800 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24652800 #FOAvip English Wikipedia <ref>{{Cite pmid|24652800}}</ref> Local Renal Circadian Clocks Control Fluid?Electrolyte Homeostasis and BP #MMPMID24652800 Tokonami N; Mordasini D; Pradervand S; Centeno G; Jouffe C; Maillard M; Bonny O; Gachon F; Gomez RA; Sequeira-Lopez MLS; Firsov D J Am Soc Nephrol 2014[Jul]; 25 (7): 1430-9 PMID24652800show ga The circadian timing system is critically involved in the maintenance of fluid and electrolyte balance and BP control. However, the role of peripheral circadian clocks in these homeostatic mechanisms remains unknown. We addressed this question in a mouse model carrying a conditional allele of the circadian clock gene Bmal1 and expressing Cre recombinase under the endogenous Renin promoter (Bmal1lox/lox/Ren1dCre mice). Analysis of Bmal1lox/lox/Ren1dCre mice showed that the floxed Bmal1 allele was excised in the kidney. In the kidney, BMAL1 protein expression was absent in the renin-secreting granular cells of the juxtaglomerular apparatus and the collecting duct. A partial reduction of BMAL1 expression was observed in the medullary thick ascending limb. Functional analyses showed that Bmal1lox/lox/Ren1dCre mice exhibited multiple abnormalities, including increased urine volume, changes in the circadian rhythm of urinary sodium excretion, increased GFR, and significantly reduced plasma aldosterone levels. These changes were accompanied by a reduction in BP. These results show that local renal circadian clocks control body fluid and BP homeostasis. äLocal Renal Circadian Clocks Control Fluid?Electrolyte Homeostasis and(epmc).pdf DeepDyve Pubget Overpricing