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Main ion channels and receptors associated with visceral hypersensitivity in
irritable bowel syndrome
#MMPMID24976114
de Carvalho Rocha HA
; Dantas BP
; Rolim TL
; Costa BA
; de Medeiros AC
Ann Gastroenterol
2014[]; 27
(3
): 200-206
PMID24976114
show ga
Irritable bowel syndrome (IBS) is a very frequent functional gastrointestinal
disorder characterized by recurrent abdominal pain or discomfort and alteration
of bowel habits. The IBS physiopathology is extremely complex. Visceral
hypersensitivity plays an important role in the pathogenesis of abdominal pain in
both in vitro and in vivo models of this functional disorder. In order to obtain
a general view of the participation of the main ion channels and receptors
regarding the visceral hypersensitivity in the IBS and to describe their chemical
structure, a literature review was carried out. A bibliographical research in the
following electronic databases: Pubmed and Virtual Library in Health (BVS) was
fulfilled by using the search terms "ion channels" "or" "receptors" "and"
"visceral hypersensitivity" "or" "visceral nociception" "and" "irritable bowel
syndrome". Original and review articles were considered for data acquisition. The
activation of the ATP ion-gated channels, voltage-gated sodium (Na(v)) and
calcium (Ca(v)) channels, as well as the activation of protease-activated
receptors (PAR2), transient receptor potential vanilloide-1, serotonin,
cannabinoids and cholecystokinin are involved in the genesis of visceral
hypersensitivity in IBS. The involvement of ion channels and receptors concerning
visceral hypersensitivity is noteworthy in IBS models.