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2013 ; 12
(3
): 525-30
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Heterochronic parabiosis: historical perspective and methodological
considerations for studies of aging and longevity
#MMPMID23489470
Conboy MJ
; Conboy IM
; Rando TA
Aging Cell
2013[Jun]; 12
(3
): 525-30
PMID23489470
show ga
Pairing two animals in parabiosis to test for systemic or circulatory factors
from one animal affecting the other animal has been used in scientific studies
for at least 150 years. These studies have led to advances in fields as diverse
as endocrinology, immunology, and oncology. A variation on the technique,
heterochronic parabiosis, whereby two animals of different ages are joined to
test for systemic regulators of aspects of aging or age-related diseases also has
almost a century-long scientific history. In this review, we focus on the history
of heterochronic parabiosis, methodological considerations and caveats, and the
major advances that have emerged from those studies, including recent advances in
our understanding of stem cell aging.