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10.1093/annonc/mdu110

http://scihub22266oqcxt.onion/10.1093/annonc/mdu110
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C4071755!4071755!24608196
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suck abstract from ncbi


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pmid24608196      Ann+Oncol 2014 ; 25 (7): 1340-6
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  • Efficacy and safety of NEPA, an oral combination of netupitant and palonosetron, for prevention of chemotherapy-induced nausea and vomiting following highly emetogenic chemotherapy: a randomized dose-ranging pivotal study #MMPMID24608196
  • Hesketh PJ; Rossi G; Rizzi G; Palmas M; Alyasova A; Bondarenko I; Lisyanskaya A; Gralla RJ
  • Ann Oncol 2014[Jul]; 25 (7): 1340-6 PMID24608196show ga
  • This study was designed to determine the appropriate clinical dose of netupitant (NETU), a new NK1 receptor antagonist (RA), to combine with the 5-HT3 RA, palonosetron (PALO) in a fixed-dose antiemetic combination (NEPA). All NEPA doses provided superior prevention of chemotherapy-induced nausea and vomiting compared with PALO, with NEPA300 (300mg NETU + 0.50 mg PALO) being the best dose studied.
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