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10.1095/biolreprod.112.099465 http://scihub22266oqcxt.onion/10.1095/biolreprod.112.099465 C4070869!4070869 !23553431     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\23553431 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Biol+Reprod 2013 ; 88 (6 ): 155 Nephropedia Template TP {{tp|p=23553431 |t=2013. Maternal decidual macrophages inhibit NK cell killing of invasive cytotrophoblasts during human pregnancy |pdf=|usr=}}{{23553431 }} gab.com Text Maternal decidual macrophages inhibit NK cell killing of invasive cytotrophoblasts during human pregnancy JO: Biol Reprod http://www.kidney.de/pget.php?&tw=1&pmid=23553431 #FOAvip Human pregnancy is an immunological paradox. Semiallogeneic (fetal) placental cells (extravillous cytotrophoblasts [CTBs]) invade the uterine lining (decidua), which contains a unique decidual natural killer (dNK) cell population, identified by the cell surface phenotype CD56(bright) CD16(-) CD3(-) and CD14(+) CD206(+) macrophages (dMac). Previous reports suggested that human dNK cells are not a threat to the fetoplacental unit because they are anergic. In contrast, here we showed that purified and exogenously stimulated dNK cells are capable killers of cellular targets, including semiallogeneic CTBs. However, dMacs in the decidual leukocyte (DL) population restrained dNK killing through a transforming growth factor beta1 (TGF-beta1)-dependent mechanism. Our findings support a new model whereby dNK cells, capable of killing CTBs, are prevented from doing so by neighboring macrophages, thus protecting the fetal cells from NK cell attack. We speculate that this mechanism would inhibit dNK cell-mediated killing, even under conditions where high levels of cytokines may stimulate dNK cells, which could pose a threat to the developing placenta. Twit Text FOAVip Maternal decidual macrophages inhibit NK cell killing of invasive cytotrophoblasts during human pregnancy ????Biol Reprod http://www.kidney.de/pget.php?&tw=1&pmid=23553431 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23553431 #FOAvip English Wikipedia <ref>{{Cite pmid|23553431 }}</ref> Maternal decidual macrophages inhibit NK cell killing of invasive cytotrophoblasts during human pregnancy #MMPMID23553431 Co EC ; Gormley M ; Kapidzic M ; Rosen DB ; Scott MA ; Stolp HA ; McMaster M ; Lanier LL ; Bárcena A ; Fisher SJ Biol Reprod 2013[Jun]; 88 (6 ): 155 PMID23553431 show ga Human pregnancy is an immunological paradox. Semiallogeneic (fetal) placental cells (extravillous cytotrophoblasts [CTBs]) invade the uterine lining (decidua), which contains a unique decidual natural killer (dNK) cell population, identified by the cell surface phenotype CD56(bright) CD16(-) CD3(-) and CD14(+) CD206(+) macrophages (dMac). Previous reports suggested that human dNK cells are not a threat to the fetoplacental unit because they are anergic. In contrast, here we showed that purified and exogenously stimulated dNK cells are capable killers of cellular targets, including semiallogeneic CTBs. However, dMacs in the decidual leukocyte (DL) population restrained dNK killing through a transforming growth factor beta1 (TGF-beta1)-dependent mechanism. Our findings support a new model whereby dNK cells, capable of killing CTBs, are prevented from doing so by neighboring macrophages, thus protecting the fetal cells from NK cell attack. We speculate that this mechanism would inhibit dNK cell-mediated killing, even under conditions where high levels of cytokines may stimulate dNK cells, which could pose a threat to the developing placenta. |CD3 Complex/metabolism [MESH] |CD56 Antigen/metabolism [MESH] |Decidua/cytology/*immunology/metabolism [MESH] |Female [MESH] |Humans [MESH] |Killer Cells, Natural/cytology/*immunology/metabolism [MESH] |Lectins, C-Type/metabolism [MESH] |Lipopolysaccharide Receptors/metabolism [MESH] |Macrophages/cytology/*immunology/metabolism [MESH] |Mannose Receptor [MESH] |Mannose-Binding Lectins/metabolism [MESH] |Pregnancy [MESH] |Receptors, Cell Surface/metabolism [MESH] |Receptors, IgG/metabolism [MESH]Maternal decidual macrophages inhibit NK cell killing of invasive cy(epmc).pdf DeepDyve Pubget Overpricing