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2009 ; 29
(7
): 765-73
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Duodenal mastocytosis, eosinophilia and intraepithelial lymphocytosis as possible
disease markers in the irritable bowel syndrome and functional dyspepsia
#MMPMID19183150
Walker MM
; Talley NJ
; Prabhakar M
; Pennaneac'h CJ
; Aro P
; Ronkainen J
; Storskrubb T
; Harmsen WS
; Zinsmeister AR
; Agreus L
Aliment Pharmacol Ther
2009[Apr]; 29
(7
): 765-73
PMID19183150
show ga
BACKGROUND: Irritable bowel syndrome (IBS) and functional dyspepsia (FD) are
common functional disorders without defined pathology. Mast cells and eosinophils
interact with T lymphocytes and may alter enteric nerve and smooth muscle
function. AIM: To examine mast cell, eosinophil and intraepithelial lymphocyte
populations in duodenal biopsies of subjects with IBS and FD. METHODS: A random
sample of an adult Swedish population (n = 1001; mean age 54 years; 51% female)
underwent upper endoscopy and biopsy; 51 cases with FD and 41 cases with IBS were
compared with 48 randomly selected controls. Eosinophils were identified by light
microscopy; mast cells by immunocytochemistry (CD117). Intraepithelial
lymphocytes were counted per 100 enterocytes. Cell counts were quantified by
counting the number per high power field (HPF) in 5HPFs in the bulb (D1) and
second part of duodenum (D2), summed over 5HPFs at each site. RESULTS: Cases and
controls showed similar demographics. Compared to controls, IELs in
IBS-constipation were significantly increased (P = 0.005). Mast cells were
significantly increased in IBS in D2 (P < 0.001), while eosinophils were
significantly increased in FD in D1 and D2 (P < 0.001). CONCLUSION: Duodenal mast
cell hyperplasia is linked to IBS and eosinophilia to FD, and duodenal biopsy may
identify subsets of these disorders.