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10.1186/1756-0381-7-9 http://scihub22266oqcxt.onion/10.1186/1756-0381-7-9 C4070098!4070098!24976866     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       BioData+Min 2014 ; 7 (ä): 9 Nephropedia Template TP {{tp|p=24976866|t=2014. An adaptive permutation approach for genome-wide association study: evaluation and recommendations for use |pdf=|usr=}}{{24976866}} gab.com Text An adaptive permutation approach for genome-wide association study: evaluation and recommendations for use JO: BioData Min http://www.kidney.de/pget.php?&tw=1&pmid=24976866 #FOAvip Background: Permutation testing is a robust and popular approach for significance testing in genomic research, which has the broad advantage of estimating significance non-parametrically, thereby safe guarding against inflated type I error rates. However, the computational efficiency remains a challenging issue that limits its wide application, particularly in genome-wide association studies (GWAS). Because of this, adaptive permutation strategies can be employed to make permutation approaches feasible. While these approaches have been used in practice, there is little research into the statistical properties of these approaches, and little guidance into the proper application of such a strategy for accurate p-value estimation at the GWAS level. Methods: In this work, we advocate an adaptive permutation procedure that is statistically valid as well as computationally feasible in GWAS. We perform extensive simulation experiments to evaluate the robustness of the approach to violations of modeling assumptions and compare the power of the adaptive approach versus standard approaches. We also evaluate the parameter choices in implementing the adaptive permutation approach to provide guidance on proper implementation in real studies. Additionally, we provide an example of the application of adaptive permutation testing on real data. Results: The results provide sufficient evidence that the adaptive test is robust to violations of modeling assumptions. In addition, even when modeling assumptions are correct, the power achieved by adaptive permutation is identical to the parametric approach over a range of significance thresholds and effect sizes under the alternative. A framework for proper implementation of the adaptive procedure is also generated. Conclusions: While the adaptive permutation approach presented here is not novel, the current study provides evidence of the validity of the approach, and importantly provides guidance on the proper implementation of such a strategy. Additionally, tools are made available to aid investigators in implementing these approaches. Twit Text FOAVip An adaptive permutation approach for genome-wide association study: evaluation and recommendations for use ????BioData Min http://www.kidney.de/pget.php?&tw=1&pmid=24976866 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24976866 #FOAvip English Wikipedia <ref>{{Cite pmid|24976866}}</ref> An adaptive permutation approach for genome-wide association study: evaluation and recommendations for use #MMPMID24976866 Che R; Jack JR; Motsinger-Reif AA; Brown CC BioData Min 2014[]; 7 (ä): 9 PMID24976866show ga Background: Permutation testing is a robust and popular approach for significance testing in genomic research, which has the broad advantage of estimating significance non-parametrically, thereby safe guarding against inflated type I error rates. However, the computational efficiency remains a challenging issue that limits its wide application, particularly in genome-wide association studies (GWAS). Because of this, adaptive permutation strategies can be employed to make permutation approaches feasible. While these approaches have been used in practice, there is little research into the statistical properties of these approaches, and little guidance into the proper application of such a strategy for accurate p-value estimation at the GWAS level. Methods: In this work, we advocate an adaptive permutation procedure that is statistically valid as well as computationally feasible in GWAS. We perform extensive simulation experiments to evaluate the robustness of the approach to violations of modeling assumptions and compare the power of the adaptive approach versus standard approaches. We also evaluate the parameter choices in implementing the adaptive permutation approach to provide guidance on proper implementation in real studies. Additionally, we provide an example of the application of adaptive permutation testing on real data. Results: The results provide sufficient evidence that the adaptive test is robust to violations of modeling assumptions. In addition, even when modeling assumptions are correct, the power achieved by adaptive permutation is identical to the parametric approach over a range of significance thresholds and effect sizes under the alternative. A framework for proper implementation of the adaptive procedure is also generated. Conclusions: While the adaptive permutation approach presented here is not novel, the current study provides evidence of the validity of the approach, and importantly provides guidance on the proper implementation of such a strategy. Additionally, tools are made available to aid investigators in implementing these approaches. äAn adaptive permutation approach for genome-wide association study: ev(epmc).pdf DeepDyve Pubget Overpricing