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Electron microscopic features of brain edema in rodent cerebral malaria in
relation to glial fibrillary acidic protein expression
#MMPMID24966914
Ampawong S
; Chaisri U
; Viriyavejakul P
; Nontprasert A
; Grau GE
; Pongponratn E
Int J Clin Exp Pathol
2014[]; 7
(5
): 2056-67
PMID24966914
show ga
The mechanisms leading to cerebral malaria (CM) are not completely understood.
Brain edema has been suggested as having an important role in experimental CM. In
this study, CBA/CaH mice were infected with Plasmodium berghei ANKA blood-stage
and when typical symptoms of CM developed on day 7, brain tissues were processed
for electron-microscopic and immunohistochemical studies. The study demonstrated
ultrastructural hallmarks of cerebral edema by perivascular edema and astroglial
dilatation confirming existing evidence of vasogenic and cytogenic edema. This
correlates closely with the clinical features of CM. An adaptive response of
astrocytic activity, represented by increasing glial fibrillary acidic protein
(GFAP) expression in the perivascular area and increasing numbers of large
astrocyte clusters were predominately found in the CM mice. The presence of
multivesicular and lamellar bodies indicates the severity of cerebral damage in
experimental CM. Congestion of the microvessels with occluded white blood cells
(WBCs), parasitized red blood cells (PRBCs) and platelets is also a crucial
covariate role for CM pathogenesis.
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