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10.18632/aging.100665 http://scihub22266oqcxt.onion/10.18632/aging.100665 C4069266!4069266 !24861087     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24861087 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Aging+(Albany+NY) 2014 ; 6 (5 ): 390-8 Nephropedia Template TP {{tp|p=24861087 |t=2014. Target of rapamycin signalling mediates the lifespan-extending effects of dietary restriction by essential amino acid alteration |pdf=|usr=}}{{24861087 }} gab.com Text Target of rapamycin signalling mediates the lifespan-extending effects of dietary restriction by essential amino acid alteration JO: Aging (Albany NY) http://www.kidney.de/pget.php?&tw=1&pmid=24861087 #FOAvip Dietary restriction (DR), defined as a moderate reduction in food intake short of malnutrition, has been shown to extend healthy lifespan in a diverse range of organisms, from yeast to primates. Reduced signalling through the insulin/IGF-like (IIS) and Target of Rapamycin (TOR) signalling pathways also extend lifespan. InDrosophila melanogaster the lifespan benefits of DR can be reproduced by modulating only the essential amino acids in yeast based food. Here, we show that pharmacological downregulation of TOR signalling, but not reduced IIS, modulates the lifespan response to DR by amino acid alteration. Of the physiological responses flies exhibit upon DR, only increased body fat and decreased heat stress resistance phenotypes correlated with longevity via reduced TOR signalling. These data indicate that lowered dietary amino acids promote longevity via TOR, not by enhanced resistance to molecular damage, but through modified physiological conditions that favour fat accumulation. Twit Text FOAVip Target of rapamycin signalling mediates the lifespan-extending effects of dietary restriction by essential amino acid alteration ????Aging (Albany NY) http://www.kidney.de/pget.php?&tw=1&pmid=24861087 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24861087 #FOAvip English Wikipedia <ref>{{Cite pmid|24861087 }}</ref> Target of rapamycin signalling mediates the lifespan-extending effects of dietary restriction by essential amino acid alteration #MMPMID24861087 Emran S ; Yang M ; He X ; Zandveld J ; Piper MD Aging (Albany NY) 2014[May]; 6 (5 ): 390-8 PMID24861087 show ga Dietary restriction (DR), defined as a moderate reduction in food intake short of malnutrition, has been shown to extend healthy lifespan in a diverse range of organisms, from yeast to primates. Reduced signalling through the insulin/IGF-like (IIS) and Target of Rapamycin (TOR) signalling pathways also extend lifespan. InDrosophila melanogaster the lifespan benefits of DR can be reproduced by modulating only the essential amino acids in yeast based food. Here, we show that pharmacological downregulation of TOR signalling, but not reduced IIS, modulates the lifespan response to DR by amino acid alteration. Of the physiological responses flies exhibit upon DR, only increased body fat and decreased heat stress resistance phenotypes correlated with longevity via reduced TOR signalling. These data indicate that lowered dietary amino acids promote longevity via TOR, not by enhanced resistance to molecular damage, but through modified physiological conditions that favour fat accumulation. |*Caloric Restriction [MESH] |Amino Acids, Essential/*metabolism [MESH] |Animals [MESH] |Blotting, Western [MESH] |Drosophila Proteins/*metabolism [MESH] |Drosophila melanogaster/metabolism [MESH] |Longevity/*physiology [MESH] |Signal Transduction/*physiology [MESH]Target of rapamycin signalling mediates the lifespan-extending effects(epmc).pdf DeepDyve Pubget Overpricing