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2014 ; 64
(1
): 86-94
Nephropedia Template TP
gab.com Text
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English Wikipedia
Recovery time, quality of life, and mortality in hemodialysis patients: the
Dialysis Outcomes and Practice Patterns Study (DOPPS)
#MMPMID24529994
Rayner HC
; Zepel L
; Fuller DS
; Morgenstern H
; Karaboyas A
; Culleton BF
; Mapes DL
; Lopes AA
; Gillespie BW
; Hasegawa T
; Saran R
; Tentori F
; Hecking M
; Pisoni RL
; Robinson BM
Am J Kidney Dis
2014[Jul]; 64
(1
): 86-94
PMID24529994
show ga
BACKGROUND: There is limited information about the clinical and prognostic
significance of patient-reported recovery time. STUDY DESIGN: Prospective cohort
study. SETTING & PARTICIPANTS: 6,040 patients in the DOPPS (Dialysis Outcomes and
Practice Patterns Study). PREDICTOR: Answer to question "How long does it take
you to recover from a dialysis session?" categorized as follows: fewer than 2,
2-6, 7-12, or longer than 12 hours. OUTCOMES & MEASUREMENTS: Cross-sectional and
longitudinal associations between recovery time and patient characteristics,
hemodialysis treatment variables, health-related quality of life (HRQoL), and
hospitalization and mortality. RESULTS: 32% reported recovery time shorter than 2
hours; 41%, 2-6 hours; 17%, 7-12 hours; and 10%, longer than 12 hours. Using
proportional odds (ordinal) logistic regression, shorter recovery time was
associated with male sex, full-time employment, and higher serum albumin level.
Longer recovery time was associated with older age, dialysis vintage, body mass
index, diabetes, and psychiatric disorder. Greater intradialytic weight loss,
longer dialysis session length, and lower dialysate sodium concentration were
associated with longer recovery time. In facilities that used uniform dialysate
sodium concentrations for ?90% of patients, the adjusted OR of longer recovery
time, comparing dialysate sodium concentration<140 vs 140 mEq/L, was 1.72 (95%
CI, 1.37-2.16). Recovery time was correlated positively with symptoms of kidney
failure and kidney disease burden score and inversely with HRQoL mental and
physical component summary scores. Using Cox regression, adjusting for potential
confounders not influenced by recovery time, it was associated positively with
first hospitalization and mortality (adjusted HRs for recovery time>12 vs 2-6
hours 1.22 [95% CI, 1.09-1.37] and 1.47 [95% CI, 1.19-1.83], respectively).
LIMITATIONS: Answers are subjective and not supported by physiologic
measurements. CONCLUSIONS: Recovery time can be used to identify patients with
poorer HRQoL and higher risks of hospitalization and mortality. Interventions to
reduce recovery time and possibly improve clinical outcomes, such as increasing
dialysate sodium concentration, need to be tested in randomized trials.