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Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Anal+Chem 2012 ; 84 (6): 2702-7 Nephropedia Template TP
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In Situ Electrokinetic Enhancement for Self-Assembled-Monolayer-Based Electrochemical Biosensing #MMPMID22397486
Sin MLY; Liu T; Pyne JD; Gau V; Liao JC; Kin Wong P
Anal Chem 2012[Mar]; 84 (6): 2702-7 PMID22397486show ga
This study reports a multifunctional electrode approach which directly implements electrokinetic enhancement on a self-assembled-monolayer-based electro-chemical sensor for point-of-care diagnostics. Using urinary tract infections as a model system, we demonstrate that electrokinetic enhancement, which involves in situ stirring and heating, can enhance the sensitivity of the strain specific 16S rRNA hybridization assay for 1 order of magnitude and accelerate the time-limiting incubation step with a 6-fold reduction in the incubation time. Since the same electrode platform is used for both electrochemical signal enhancement and electrochemical sensing, the multifunctional electrode approach provides a highly effective strategy toward fully integrated lab-on-a-chip systems for various biomedical applications.