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10.1021/cb500135f http://scihub22266oqcxt.onion/10.1021/cb500135f C4068217!4068217!24669831     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       ACS+Chem+Biol 2014 ; 9 (6): 1251-6 Nephropedia Template TP {{tp|p=24669831|t=2014. An Inhibitor?s-Eye View of the ATP-Binding Site of CDKs in Different Regulatory States |pdf=|usr=}}{{24669831}} gab.com Text An Inhibitor s-Eye View of the ATP-Binding Site of CDKs in Different Regulatory States JO: ACS Chem Biol http://www.kidney.de/pget.php?&tw=1&pmid=24669831 #FOAvip We have used a chemically diverse panel of kinase inhibitors to assess the chemical similarity of the ATP-binding sites of cyclin-dependent kinase (CDK) subfamily members in a range of activation states. Using this approach, we find that different activation states of a particular CDK may differ from each other as much as different CDKs in the same activation state. We also find that inhibitors discriminate more effectively among CDK family members in their monomeric state than in their cyclin-bound state, providing direct evidence for the belief that selective binding to inactive kinase states might be more readily achieved than selective binding to active states. Twit Text FOAVip An Inhibitor s-Eye View of the ATP-Binding Site of CDKs in Different Regulatory States ????ACS Chem Biol http://www.kidney.de/pget.php?&tw=1&pmid=24669831 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24669831 #FOAvip English Wikipedia <ref>{{Cite pmid|24669831}}</ref> An Inhibitor?s-Eye View of the ATP-Binding Site of CDKs in Different Regulatory States #MMPMID24669831 Echalier A; Hole AJ; Lolli G; Endicott JA; Noble MEM ACS Chem Biol 2014[Jun]; 9 (6): 1251-6 PMID24669831show ga We have used a chemically diverse panel of kinase inhibitors to assess the chemical similarity of the ATP-binding sites of cyclin-dependent kinase (CDK) subfamily members in a range of activation states. Using this approach, we find that different activation states of a particular CDK may differ from each other as much as different CDKs in the same activation state. We also find that inhibitors discriminate more effectively among CDK family members in their monomeric state than in their cyclin-bound state, providing direct evidence for the belief that selective binding to inactive kinase states might be more readily achieved than selective binding to active states. äAn Inhibitor?s-Eye View of the ATP-Binding Site of CDKs in Different R(epmc).pdf DeepDyve Pubget Overpricing