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2010 ; 127
(4
): 768-79
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Cancer inflammation and regulatory T cells
#MMPMID20518013
Erdman SE
; Poutahidis T
Int J Cancer
2010[Aug]; 127
(4
): 768-79
PMID20518013
show ga
Chronic inflammation is essential for cancer growth and metastasis. It follows
that factors reducing inflammation would abrogate cancer and restore tissue
health. However, roles for anti-inflammatory CD4+ regulatory cells (T(REG)) in
cancer are enigmatic and controversial. Our recent data reveal that T(REG) may
function in cancer similarly to inflammatory bowel disease or multiple sclerosis,
whereby T(REG) accumulate but lack potency to restore tissue homeostasis under
inflammatory conditions. Interestingly, early life exposures to diverse
environmental organisms reinforce a protective T(REG) phenotype that inhibits
cancer. In contrast, hygienic individuals with few exposures earlier in life
suffer from a dysregulated T(REG) feedback loop. Consequently, hygienic subjects
have increased risk of malignancy later in life. This cancer condition is
reversible by blocking underlying inflammation. Taken together, these data help
explain increased inflammation-associated cancer rates in hygienic societies and
identify targets to abrogate cancer and restore overall health.
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