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10.1002/ijc.25430 http://scihub22266oqcxt.onion/10.1002/ijc.25430 C4068033!4068033 !20518013     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=20518013 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\20518013 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Int+J+Cancer 2010 ; 127 (4 ): 768-79 Nephropedia Template TP {{tp|p=20518013 |t=2010. Cancer inflammation and regulatory T cells |pdf=|usr=}}{{20518013 }} gab.com Text Cancer inflammation and regulatory T cells JO: Int J Cancer http://www.kidney.de/pget.php?&tw=1&pmid=20518013 #FOAvip Chronic inflammation is essential for cancer growth and metastasis. It follows that factors reducing inflammation would abrogate cancer and restore tissue health. However, roles for anti-inflammatory CD4+ regulatory cells (T(REG)) in cancer are enigmatic and controversial. Our recent data reveal that T(REG) may function in cancer similarly to inflammatory bowel disease or multiple sclerosis, whereby T(REG) accumulate but lack potency to restore tissue homeostasis under inflammatory conditions. Interestingly, early life exposures to diverse environmental organisms reinforce a protective T(REG) phenotype that inhibits cancer. In contrast, hygienic individuals with few exposures earlier in life suffer from a dysregulated T(REG) feedback loop. Consequently, hygienic subjects have increased risk of malignancy later in life. This cancer condition is reversible by blocking underlying inflammation. Taken together, these data help explain increased inflammation-associated cancer rates in hygienic societies and identify targets to abrogate cancer and restore overall health. Twit Text FOAVip Cancer inflammation and regulatory T cells ????Int J Cancer http://www.kidney.de/pget.php?&tw=1&pmid=20518013 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=20518013 #FOAvip English Wikipedia <ref>{{Cite pmid|20518013 }}</ref> Cancer inflammation and regulatory T cells #MMPMID20518013 Erdman SE ; Poutahidis T Int J Cancer 2010[Aug]; 127 (4 ): 768-79 PMID20518013 show ga Chronic inflammation is essential for cancer growth and metastasis. It follows that factors reducing inflammation would abrogate cancer and restore tissue health. However, roles for anti-inflammatory CD4+ regulatory cells (T(REG)) in cancer are enigmatic and controversial. Our recent data reveal that T(REG) may function in cancer similarly to inflammatory bowel disease or multiple sclerosis, whereby T(REG) accumulate but lack potency to restore tissue homeostasis under inflammatory conditions. Interestingly, early life exposures to diverse environmental organisms reinforce a protective T(REG) phenotype that inhibits cancer. In contrast, hygienic individuals with few exposures earlier in life suffer from a dysregulated T(REG) feedback loop. Consequently, hygienic subjects have increased risk of malignancy later in life. This cancer condition is reversible by blocking underlying inflammation. Taken together, these data help explain increased inflammation-associated cancer rates in hygienic societies and identify targets to abrogate cancer and restore overall health. |Animals [MESH] |Humans [MESH] |Inflammation/*immunology [MESH] |Neoplasms/*immunology [MESH] |Prognosis [MESH]Cancer inflammation and regulatory T cells (epmc).pdf DeepDyve Pubget Overpricing