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10.4049/jimmunol.1400168 http://scihub22266oqcxt.onion/10.4049/jimmunol.1400168 C4067873!4067873 !24850725     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24850725 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Immunol 2014 ; 193 (1 ): 379-90 Nephropedia Template TP {{tp|p=24850725 |t=2014. Signal transduction by different forms of the ?? T cell-specific pattern recognition receptor WC1 |pdf=|usr=}}{{24850725 }} gab.com Text Signal transduction by different forms of the T cell-specific pattern recognition receptor WC1 JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=24850725 #FOAvip WC1 coreceptors are scavenger receptor cysteine-rich (SRCR) family members, related to T19 in sheep, SCART in mice, and CD163c-? in humans, and form a 13-member subfamily in cattle exclusively expressed on ?? T cells. Subpopulations of ?? T cells are defined by anti-WC1 mAbs and respond to different pathogen species accordingly. In this study, variegated WC1 gene expression within subpopulations and differences in signaling and cell activation due to endodomain sequences are described. The endodomains designated types I to III differ by a 15- or 18-aa insert in type II and an additional 80 aa containing an additional eight tyrosines for type III. Anti-WC1 mAbs enhanced cell proliferation of ?? T cells when cross-linked with the TCR regardless of the endodomain sequences. Chimeric molecules of human CD4 ectodomain with WC1 endodomains transfected into Jurkat cells showed that the tyrosine phosphorylation of the type II was the same as that of the previously reported archetypal sequence (type I) with only Y24EEL phosphorylated, whereas for type III only Y199DDV and Y56TGD were phosphorylated despite conservation of the Y24EEL/Y24QEI and Y199DDV/I tyrosine motifs among the three types. Time to maximal phosphorylation was more rapid with type III endodomains and sustained longer. Differences in tyrosine phosphorylation were associated with differences in function in that cross-linking of type III chimeras with TCR resulted in significantly greater IL-2 production. Identification of differences in the signal transduction through the endodomains of WC1 contributes to understanding the functional role of the WC1 coreceptors in the ?? T cell responses. Twit Text FOAVip Signal transduction by different forms of the T cell-specific pattern recognition receptor WC1 ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=24850725 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24850725 #FOAvip English Wikipedia <ref>{{Cite pmid|24850725 }}</ref> Signal transduction by different forms of the ?? T cell-specific pattern recognition receptor WC1 #MMPMID24850725 Chen C ; Hsu H ; Hudgens E ; Telfer JC ; Baldwin CL J Immunol 2014[Jul]; 193 (1 ): 379-90 PMID24850725 show ga WC1 coreceptors are scavenger receptor cysteine-rich (SRCR) family members, related to T19 in sheep, SCART in mice, and CD163c-? in humans, and form a 13-member subfamily in cattle exclusively expressed on ?? T cells. Subpopulations of ?? T cells are defined by anti-WC1 mAbs and respond to different pathogen species accordingly. In this study, variegated WC1 gene expression within subpopulations and differences in signaling and cell activation due to endodomain sequences are described. The endodomains designated types I to III differ by a 15- or 18-aa insert in type II and an additional 80 aa containing an additional eight tyrosines for type III. Anti-WC1 mAbs enhanced cell proliferation of ?? T cells when cross-linked with the TCR regardless of the endodomain sequences. Chimeric molecules of human CD4 ectodomain with WC1 endodomains transfected into Jurkat cells showed that the tyrosine phosphorylation of the type II was the same as that of the previously reported archetypal sequence (type I) with only Y24EEL phosphorylated, whereas for type III only Y199DDV and Y56TGD were phosphorylated despite conservation of the Y24EEL/Y24QEI and Y199DDV/I tyrosine motifs among the three types. Time to maximal phosphorylation was more rapid with type III endodomains and sustained longer. Differences in tyrosine phosphorylation were associated with differences in function in that cross-linking of type III chimeras with TCR resulted in significantly greater IL-2 production. Identification of differences in the signal transduction through the endodomains of WC1 contributes to understanding the functional role of the WC1 coreceptors in the ?? T cell responses. |Animals [MESH] |Antibodies, Monoclonal, Murine-Derived/pharmacology [MESH] |Antigens, CD/genetics/immunology [MESH] |Antigens, Differentiation, Myelomonocytic/genetics/immunology [MESH] |CD163 Antigen [MESH] |Cattle [MESH] |HEK293 Cells [MESH] |Humans [MESH] |Interleukin-2/genetics/immunology [MESH] |Jurkat Cells [MESH] |Membrane Glycoproteins/genetics/*immunology [MESH] |Mice [MESH] |Phosphorylation/drug effects/immunology [MESH] |Protein Structure, Tertiary [MESH] |Receptors, Antigen, T-Cell, gamma-delta/genetics/*immunology [MESH] |Receptors, Cell Surface/genetics/immunology [MESH] |Signal Transduction/drug effects/genetics/*immunology [MESH]Signal transduction by different forms of the ?? T cell-specific patte(epmc).pdf DeepDyve Pubget Overpricing