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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 AJNR+Am+J+Neuroradiol
2010 ; 31
(10
): 1911-6
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Endovascular treatment of medically refractory cerebral vasospasm following
aneurysmal subarachnoid hemorrhage
#MMPMID20616179
Jun P
; Ko NU
; English JD
; Dowd CF
; Halbach VV
; Higashida RT
; Lawton MT
; Hetts SW
AJNR Am J Neuroradiol
2010[Nov]; 31
(10
): 1911-6
PMID20616179
show ga
BACKGROUND AND PURPOSE: CV following aneurysmal SAH is a significant cause of
morbidity and mortality. We review our experiences using PTA and IA verapamil
infusion for treating medically refractory cases. MATERIALS AND METHODS: We
performed a retrospective review of patients with SAH admitted from July 2003 to
January 2008. RESULTS: Of 546 patients admitted within 72 hours of symptom onset,
231 patients (42%) developed symptomatic CV and 189 patients (35%) required
endovascular therapy. A total of 346 endovascular sessions were performed
consisting of 1 single angioplasty, 286 IA verapamil infusions, and 59 combined
treatments. PTA was performed on 151 vessel segments, and IA verapamil was
infused in 720 vessel segments. IA verapamil doses ranged from 2.0 to 30.0 mg per
vessel segment and from 3.0 to 55.0 mg per treatment session. Repeat treatments
were necessary in 102 patients (54%) for persistent, recurrent, or worsening CV.
There were 6 treatment-related complications, of which 2 resulted in clinical
worsening. No deaths were attributable to endovascular therapy. At follow-up, 115
patients (61%) had a good outcome and 55 patients (29%) had a poor outcome.
Sixteen patients died from causes related to SAH, while 3 died from other medical
complications. CONCLUSIONS: Endovascular treatments are an integral part of
managing patients with medically refractory CV. In our experience, PTA and IA
verapamil are safe, with a low complication rate, but further studies are
required to determine appropriate patient selection and treatment efficacy.