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10.1074/jbc.M113.515262

http://scihub22266oqcxt.onion/10.1074/jbc.M113.515262
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C4067224!4067224!24811165
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suck abstract from ncbi


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pmid24811165      J+Biol+Chem 2014 ; 289 (25): 17941-50
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  • Insulin-like Growth Factor-2 Enhances Functions of Antigen (Ag)-specific Regulatory B Cells* #MMPMID24811165
  • Geng XR; Yang G; Li M; Song JP; Liu ZQ; Qiu S; Liu Z; Yang PC
  • J Biol Chem 2014[Jun]; 289 (25): 17941-50 PMID24811165show ga
  • Background: Antigen-specific B cells (AgsBCs) are important in immune regulation.Results: AgsBCs express IGF2 receptor. IGF2 can drive AgsBCs to produce IL-10 and differentiate to regulatory B cells.Conclusion: IGF2 can enhance the immune suppressor function of AgsBCs.Significance: IGF2 has the potential to enhance immunotherapy of allergic disorders.
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