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10.1074/jbc.M114.557439

http://scihub22266oqcxt.onion/10.1074/jbc.M114.557439
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C4067222!4067222!24825898
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suck abstract from ncbi


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pmid24825898      J+Biol+Chem 2014 ; 289 (25): 17917-31
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  • A Neuroprotective Brain-penetrating Endopeptidase Fusion Protein Ameliorates Alzheimer Disease Pathology and Restores Neurogenesis* #MMPMID24825898
  • Spencer B; Verma I; Desplats P; Morvinski D; Rockenstein E; Adame A; Masliah E
  • J Biol Chem 2014[Jun]; 289 (25): 17917-31 PMID24825898show ga
  • Background: Development of new therapeutic approaches for Alzheimer disease (AD) is crucial.Results: A recombinant enzyme engineered to cross the blood-brain barrier treats the accumulation of A? in a mouse model.Conclusion: This study shows a therapy can improve the symptoms of AD while also increasing the population of new neurons.Significance: The enzyme could be delivered weekly or even monthly to patients.
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