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10.1074/jbc.M113.541094

http://scihub22266oqcxt.onion/10.1074/jbc.M113.541094
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C4067207!4067207!24808179
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suck abstract from ncbi


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pmid24808179      J+Biol+Chem 2014 ; 289 (25): 17732-46
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  • Annexin A2 Reduces PCSK9 Protein Levels via a Translational Mechanism and Interacts with the M1 and M2 Domains of PCSK9* #MMPMID24808179
  • Ly K; Luna Saavedra YG; Canuel M; Routhier S; Desjardins R; Hamelin J; Mayne J; Lazure C; Seidah NG; Day R
  • J Biol Chem 2014[Jun]; 289 (25): 17732-46 PMID24808179show ga
  • Background: Annexin A2 (AnxA2) is an extracellular endogenous inhibitor of the PCSK9-LDLR protein-protein interaction.Results: AnxA2 mRNA knockdown in Huh7 cells increases PCSK9 protein levels, and its overexpression in HepG2 cells has the opposite effect.Conclusion: AnxA2 inhibits mRNA translation of PCSK9 and interacts with the M1 + M2 domains of PCSK9.Significance: AnxA2 is a negative regulator of PCSK9 protein levels and activity.
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