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10.1074/jbc.M113.527622

http://scihub22266oqcxt.onion/10.1074/jbc.M113.527622
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C4067186!4067186!24825897
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suck abstract from ncbi


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pmid24825897      J+Biol+Chem 2014 ; 289 (25): 17480-96
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  • Evidence toward a Dual Phosphatase Mechanism That Restricts Aurora A (Thr-295) Phosphorylation during the Early Embryonic Cell Cycle* #MMPMID24825897
  • Kang Q; Srividhya J; Ipe J; Pomerening JR
  • J Biol Chem 2014[Jun]; 289 (25): 17480-96 PMID24825897show ga
  • Background: Aurora A is a spindle-regulating mitotic kinase that has been implicated in controlling CDK1 activation.Results: Inducing an abnormal increase in Aurora A(Thr-295) phosphorylation during late interphase delays CDK1 activation.Conclusion: Aurora A (Thr-295) phosphorylation during late interphase competes for phosphatase activity that also promotes CDK1 activation.Significance: Learning how kinases and phosphatases function as a system is essential to understand cell cycle control.
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