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10.1074/jbc.M114.555714

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C4067164!4067164!24778187
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suck abstract from ncbi


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pmid24778187      J+Biol+Chem 2014 ; 289 (25): 17280-98
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  • Insulin-regulated Glut4 Translocation: MEMBRANE PROTEIN TRAFFICKING WITH SIX DISTINCTIVE STEPS* #MMPMID24778187
  • Brewer PD; Habtemichael EN; Romenskaia I; Mastick CC; Coster ACF
  • J Biol Chem 2014[Jun]; 289 (25): 17280-98 PMID24778187show ga
  • Background: Cell surface levels of glucose transporter Glut4 are tightly controlled in adipocytes.Results: The effects of insulin and differentiation on the trafficking kinetics of Glut4, the transferrin receptor, and LRP1 were measured to identify regulatory steps.Conclusion: Six independent steps determine cell surface Glut4; insulin stimulates three of these.Significance: These results provide a framework for functionally mapping treatments/proteins that affect Glut4 translocation.
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