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10.1038/nrd4226 http://scihub22266oqcxt.onion/10.1038/nrd4226 C4067137!4067137!24625825     free     free     free       Nat+Rev+Drug+Discov 2014 ; 13 (4): 259-77 Nephropedia Template TP {{tp|p=24625825|t=2014. Aquaporins: important but elusive drug targets |pdf=|usr=}}{{24625825}} gab.com Text Aquaporins: important but elusive drug targets JO: Nat Rev Drug Discov http://www.kidney.de/pget.php?&tw=1&pmid=24625825 #FOAvip The aquaporins (AQPs) are a family of small, integral membrane proteins that facilitate water transport across the plasma membranes of cells in response to osmotic gradients. Data from knockout mice support the involvement of AQPs in epithelial fluid secretion, cell migration, brain oedema and adipocyte metabolism, which suggests that modulation of AQP function or expression could have therapeutic potential in oedema, cancer, obesity, brain injury, glaucoma and several other conditions. Moreover, loss-of-function mutations in human AQPs cause congenital cataracts (AQP0) and nephrogenic diabetes insipidus (AQP2), and autoantibodies against AQP4 cause the autoimmune demyelinating disease neuromyelitis optica. Although some potential AQP modulators have been identified, challenges associated with the development of better modulators include the druggability of the target and the suitability of the assay methods used to identify modulators. Twit Text FOAVip Aquaporins: important but elusive drug targets ????Nat Rev Drug Discov http://www.kidney.de/pget.php?&tw=1&pmid=24625825 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24625825 #FOAvip English Wikipedia <ref>{{Cite pmid|24625825}}</ref> Aquaporins: important but elusive drug targets #MMPMID24625825 Verkman AS; Anderson MO; Papadopoulos MC Nat Rev Drug Discov 2014[Apr]; 13 (4): 259-77 PMID24625825show ga The aquaporins (AQPs) are a family of small, integral membrane proteins that facilitate water transport across the plasma membranes of cells in response to osmotic gradients. Data from knockout mice support the involvement of AQPs in epithelial fluid secretion, cell migration, brain oedema and adipocyte metabolism, which suggests that modulation of AQP function or expression could have therapeutic potential in oedema, cancer, obesity, brain injury, glaucoma and several other conditions. Moreover, loss-of-function mutations in human AQPs cause congenital cataracts (AQP0) and nephrogenic diabetes insipidus (AQP2), and autoantibodies against AQP4 cause the autoimmune demyelinating disease neuromyelitis optica. Although some potential AQP modulators have been identified, challenges associated with the development of better modulators include the druggability of the target and the suitability of the assay methods used to identify modulators. äAquaporins: important but elusive drug targets (epmc).pdf DeepDyve Pubget Overpricing