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10.2214/AJR.12.10102

http://scihub22266oqcxt.onion/10.2214/AJR.12.10102
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C4067052!4067052!23971478
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suck abstract from ncbi


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pmid23971478      AJR+Am+J+Roentgenol 2013 ; 201 (3): W460-70
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  • Relationships Between Airflow Obstruction and Quantitative CT Measurements of Emphysema, Air Trapping, and Airways in Subjects With and Without Chronic Obstructive Pulmonary Disease #MMPMID23971478
  • Schroeder JD; McKenzie AS; Zach JA; Wilson CG; Curran-Everett D; Stinson DS; Newell JD; Lynch DA
  • AJR Am J Roentgenol 2013[Sep]; 201 (3): W460-70 PMID23971478show ga
  • OBJECTIVE: This study evaluates the relationships between quantitative CT (QCT) and spirometric measurements of disease severity in cigarette smokers with and without chronic obstructive pulmonary disease (COPD). MATERIALS AND METHODS: Inspiratory and expiratory CT scans of 4062 subjects in the Genetic Epidemiology of COPD (COPDGene) Study were evaluated. Measures examined included emphysema, defined as the percentage of low-attenuation areas ? ?950 HU on inspiratory CT, which we refer to as ?LAA-950I?; air trapping, defined as the percentage of low-attenuation areas ? ?856 HU on expiratory CT, which we refer to as ?LAA-856E?; and the inner diameter, inner and outer areas, wall area, airway wall thickness, and square root of the wall area of a hypothetical airway of 10-mm internal perimeter of segmental and subsegmental airways. Correlations were determined between spirometry and several QCT measures using statistics software (SAS, version 9.2). RESULTS: QCT measurements of low-attenuation areas correlate strongly and significantly (p < 0.0001) with spirometry. The correlation between LAA-856E and forced expiratory volume in 1 second (FEV1) and the ratio of FEV1 to forced vital capacity (FVC) (r = ?0.77 and ?0.84, respectively) is stronger than the correlation between LAA-950I and FEV1 and FEV1/FVC (r = ?0.67 and r = ?0.76). Inspiratory and expiratory volume changes decreased with increasing disease severity, as measured by the Global Initiative for Chronic Obstructive Pulmonary Disease (GOLD) staging system (p < 0.0001). When airway variables were included with low-attenuation area measures in a multiple regression model, the model accounted for a statistically greater proportion of variation in FEV1 and FEV1/FVC (R2 = 0.72 and 0.77, respectively). Airway measurements alone are less correlated with spirometric measures of FEV1 (r = 0.15 to ?0.44) and FEV1/FVC (r = 0.19 to ?0.34). CONCLUSION: QCT measurements are strongly associated with spirometric results showing impairment in smokers. LAA-856E strongly correlates with physiologic measurements of airway obstruction. Airway measurements can be used concurrently with QCT measures of low-attenuation areas to accurately predict lung function.
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