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10.1016/j.immuni.2014.04.004 http://scihub22266oqcxt.onion/10.1016/j.immuni.2014.04.004 C4066874!4066874!24745332     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Immunity 2014 ; 40 (4): 477-89 Nephropedia Template TP {{tp|p=24745332|t=2014. Small molecule ROR?t antagonists inhibit T helper 17 cell transcriptional network by divergent mechanisms |pdf=|usr=}}{{24745332}} gab.com Text Small molecule ROR t antagonists inhibit T helper 17 cell transcriptional network by divergent mechanisms JO: Immunity http://www.kidney.de/pget.php?&tw=1&pmid=24745332 #FOAvip We identified three ROR?t-specific inhibitors that suppress T helper 17 (Th17) cell responses including Th17 cell-mediated autoimmune disease. We systemically characterized ROR?t binding in the presence and absence of drug with corresponding whole-genome transcriptome sequencing. ROR?t acts both as a direct activator of Th17 cell signature genes and as a direct repressor of signature genes from other T-cell lineages, with the strongest transcriptional effects on cis-regulatory sites containing the ROR? binding motif. ROR?t is central in a densely interconnected regulatory network that shapes the balance of T-cell differentiation. The three inhibitors identified here modulated the ROR?t-dependent transcriptional network to varying extents and through distinct mechanisms. Whereas one inhibitor displaced ROR?t from its target-loci, the two more potent inhibitors affected transcription predominantly without removing DNA-binding. Our work illustrates the power of a system-scale analysis of transcriptional regulation to characterize potential therapeutic compounds that inhibit pathogenic Th17 cells and suppress autoimmunity. Twit Text FOAVip Small molecule ROR t antagonists inhibit T helper 17 cell transcriptional network by divergent mechanisms ????Immunity http://www.kidney.de/pget.php?&tw=1&pmid=24745332 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24745332 #FOAvip English Wikipedia <ref>{{Cite pmid|24745332}}</ref> Small molecule ROR?t antagonists inhibit T helper 17 cell transcriptional network by divergent mechanisms #MMPMID24745332 Xiao S; Yosef N; Yang J; Wang Y; Zhou L; Zhu C; Wu C; Baloglu E; Schmidt D; Ramesh R; Lobera M; Sundrud MS; Tsai PY; Xiang Z; Wang J; Xu Y; Lin X; Kretschmer K; Rahl PB; Young RA; Zhong Z; Hafler DA; Regev A; Ghosh S; Marson A; Kuchroo VK Immunity 2014[Apr]; 40 (4): 477-89 PMID24745332show ga We identified three ROR?t-specific inhibitors that suppress T helper 17 (Th17) cell responses including Th17 cell-mediated autoimmune disease. We systemically characterized ROR?t binding in the presence and absence of drug with corresponding whole-genome transcriptome sequencing. ROR?t acts both as a direct activator of Th17 cell signature genes and as a direct repressor of signature genes from other T-cell lineages, with the strongest transcriptional effects on cis-regulatory sites containing the ROR? binding motif. ROR?t is central in a densely interconnected regulatory network that shapes the balance of T-cell differentiation. The three inhibitors identified here modulated the ROR?t-dependent transcriptional network to varying extents and through distinct mechanisms. Whereas one inhibitor displaced ROR?t from its target-loci, the two more potent inhibitors affected transcription predominantly without removing DNA-binding. Our work illustrates the power of a system-scale analysis of transcriptional regulation to characterize potential therapeutic compounds that inhibit pathogenic Th17 cells and suppress autoimmunity. äSmall molecule ROR?t antagonists inhibit T helper 17 cell transcriptio(epmc).pdf DeepDyve Pubget Overpricing