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10.1146/annurev.cellbio.24.110707.175355 http://scihub22266oqcxt.onion/10.1146/annurev.cellbio.24.110707.175355 C4066667!4066667!18588486     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Annu+Rev+Cell+Dev+Biol 2008 ; 24 (ä): 263-86 Nephropedia Template TP {{tp|p=18588486|t=2008. Regulation of Spermatogonial Stem Cell Self-Renewal in Mammals |pdf=|usr=}}{{18588486}} gab.com Text Regulation of Spermatogonial Stem Cell Self-Renewal in Mammals JO: Annu Rev Cell Dev Biol http://www.kidney.de/pget.php?&tw=1&pmid=18588486 #FOAvip Mammalian spermatogenesis is a classic adult stem cell?dependent process, supported by self-renewal and differentiation of spermatogonial stem cells (SSCs). Studying SSCs provides a model to better understand adult stem cell biology, and deciphering the mechanisms that control SSC functions may lead to treatment of male infertility and an understanding of the etiology of testicular germ cell tumor formation. Self-renewal of rodent SSCs is greatly influenced by the niche factor glial cell line?derived neurotrophic factor (GDNF). In mouse SSCs, GDNF activation upregulates expression of the transcription factor?encoding genes bcl6b, etv5, and lhx1, which influence SSC self-renewal. Additionally, the non-GDNF-stimulated transcription factors Plzf and Taf4b have been implicated in regulating SSC functions. Together, these molecules are part of a robust gene network controlling SSC fate decisions that may parallel the regulatory networks in other adult stem cell populations. Twit Text FOAVip Regulation of Spermatogonial Stem Cell Self-Renewal in Mammals ????Annu Rev Cell Dev Biol http://www.kidney.de/pget.php?&tw=1&pmid=18588486 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=18588486 #FOAvip English Wikipedia <ref>{{Cite pmid|18588486}}</ref> Regulation of Spermatogonial Stem Cell Self-Renewal in Mammals #MMPMID18588486 Oatley JM; Brinster RL Annu Rev Cell Dev Biol 2008[]; 24 (ä): 263-86 PMID18588486show ga Mammalian spermatogenesis is a classic adult stem cell?dependent process, supported by self-renewal and differentiation of spermatogonial stem cells (SSCs). Studying SSCs provides a model to better understand adult stem cell biology, and deciphering the mechanisms that control SSC functions may lead to treatment of male infertility and an understanding of the etiology of testicular germ cell tumor formation. Self-renewal of rodent SSCs is greatly influenced by the niche factor glial cell line?derived neurotrophic factor (GDNF). In mouse SSCs, GDNF activation upregulates expression of the transcription factor?encoding genes bcl6b, etv5, and lhx1, which influence SSC self-renewal. Additionally, the non-GDNF-stimulated transcription factors Plzf and Taf4b have been implicated in regulating SSC functions. Together, these molecules are part of a robust gene network controlling SSC fate decisions that may parallel the regulatory networks in other adult stem cell populations. äRegulation of Spermatogonial Stem Cell Self-Renewal in Mammals (epmc).pdf DeepDyve Pubget Overpricing