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10.1038/ni.2766 http://scihub22266oqcxt.onion/10.1038/ni.2766 C4066330!4066330!24270516     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Immunol 2014 ; 15 (1): 63-71 Nephropedia Template TP {{tp|p=24270516|t=2014. GEF-H1 controls microtubule-dependent sensing of nucleic acids for antiviral host defenses |pdf=|usr=}}{{24270516}} gab.com Text GEF-H1 controls microtubule-dependent sensing of nucleic acids for antiviral host defenses JO: Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=24270516 #FOAvip Detailed understanding of the signaling intermediates that confer the sensing of intracellular viral nucleic acids for induction of type I interferons is critical for strategies to curtail viral mechanisms that impede innate immune defenses. Here we show that the activation of the microtubule-associated guanine nucleotide exchange factor GEF-H1, encoded by Arhgef2, is essential for sensing of foreign RNA by RIG-I-like receptors. Activation of GEF-H1 controls RIG-I and Mda5-dependent phosphorylation of IRF3 and induction of interferon-? expression in macrophages. Generation of Arhgef2?/? mice revealed a pronounced signaling defect that prevented antiviral host responses to encephalomyocarditis virus and influenza A virus. Microtubule networks sequester GEF-H1 that upon activation is released to enable antiviral signaling by intracellular nucleic acid detection pathways. Twit Text FOAVip GEF-H1 controls microtubule-dependent sensing of nucleic acids for antiviral host defenses ????Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=24270516 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24270516 #FOAvip English Wikipedia <ref>{{Cite pmid|24270516}}</ref> GEF-H1 controls microtubule-dependent sensing of nucleic acids for antiviral host defenses #MMPMID24270516 Chiang HS; Zhao Y; Song JH; Liu S; Wang N; Terhorst C; Sharpe AH; Basavappa M; Jeffrey KL; Reinecker HC Nat Immunol 2014[Jan]; 15 (1): 63-71 PMID24270516show ga Detailed understanding of the signaling intermediates that confer the sensing of intracellular viral nucleic acids for induction of type I interferons is critical for strategies to curtail viral mechanisms that impede innate immune defenses. Here we show that the activation of the microtubule-associated guanine nucleotide exchange factor GEF-H1, encoded by Arhgef2, is essential for sensing of foreign RNA by RIG-I-like receptors. Activation of GEF-H1 controls RIG-I and Mda5-dependent phosphorylation of IRF3 and induction of interferon-? expression in macrophages. Generation of Arhgef2?/? mice revealed a pronounced signaling defect that prevented antiviral host responses to encephalomyocarditis virus and influenza A virus. Microtubule networks sequester GEF-H1 that upon activation is released to enable antiviral signaling by intracellular nucleic acid detection pathways. äGEF-H1 controls microtubule-dependent sensing of nucleic acids for ant(epmc).pdf DeepDyve Pubget Overpricing