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http://scihub22266oqcxt.onion/ C4065402!4065402!24959376     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Cancer+Res 2014 ; 4 (3): 211-21 Nephropedia Template TP {{tp|p=24959376|t=2014. Histone/protein deacetylase SIRT1 is an anticancer therapeutic target |pdf=|usr=}}{{24959376}} gab.com Text Histone/protein deacetylase SIRT1 is an anticancer therapeutic target JO: Am J Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=24959376 #FOAvip SIRT1, a member of the NAD+-dependent histone/protein deacetylase family, is involved in chromatin remodeling, DNA repair, and stress response and is a potential drug target. 5-fluorouracil (FU) and the SN1-type DNA methylating agent temozolomide (TMZ) are anticancer agents. In this study, we demonstrate that sirt1 knockout mouse embryonic fibroblast cells are more sensitive to FU and DNA methylating agents than normal cells. Based on these findings, the chemotherapy efficacy of SIRT1 inhibitors in combination with FU or TMZ were tested with human breast cancer cells. We found that treatments combining SIRT1 inhibitors with FU or TMZ show synergistic reduction of cell viability and colony formation of breast cancer cells. Thus, inhibition of SIRT1 activity provides a novel anticancer strategy. Twit Text FOAVip Histone/protein deacetylase SIRT1 is an anticancer therapeutic target ????Am J Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=24959376 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24959376 #FOAvip English Wikipedia <ref>{{Cite pmid|24959376}}</ref> Histone/protein deacetylase SIRT1 is an anticancer therapeutic target #MMPMID24959376 Hwang BJ; Madabushi A; Jin J; Lin SYS; Lu AL Am J Cancer Res 2014[]; 4 (3): 211-21 PMID24959376show ga SIRT1, a member of the NAD+-dependent histone/protein deacetylase family, is involved in chromatin remodeling, DNA repair, and stress response and is a potential drug target. 5-fluorouracil (FU) and the SN1-type DNA methylating agent temozolomide (TMZ) are anticancer agents. In this study, we demonstrate that sirt1 knockout mouse embryonic fibroblast cells are more sensitive to FU and DNA methylating agents than normal cells. Based on these findings, the chemotherapy efficacy of SIRT1 inhibitors in combination with FU or TMZ were tested with human breast cancer cells. We found that treatments combining SIRT1 inhibitors with FU or TMZ show synergistic reduction of cell viability and colony formation of breast cancer cells. Thus, inhibition of SIRT1 activity provides a novel anticancer strategy. äHistone/protein deacetylase SIRT1 is an anticancer therapeutic target (epmc).pdf DeepDyve Pubget Overpricing