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10.1111/joim.12224 http://scihub22266oqcxt.onion/10.1111/joim.12224 C4065203!4065203!24635672     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Intern+Med 2014 ; 276 (1): 5-11 Nephropedia Template TP {{tp|p=24635672|t=2014. Epigenetic stochasticity, nuclear structure and cancer: the implications for medicine |pdf=|usr=}}{{24635672}} gab.com Text Epigenetic stochasticity, nuclear structure and cancer: the implications for medicine JO: J Intern Med http://www.kidney.de/pget.php?&tw=1&pmid=24635672 #FOAvip The aim of this review is to summarize an evolution of thinking about the epigenetic basis of human cancer, from the earliest studies of altered DNA methylation in cancer to the modern comprehensive epigenomic era. Converging data from epigenetic studies of primary cancers and from experimental studies of chromatin in development and epithelial?mesenchymal transition suggest a role for epigenetic stochasticity as a driving force of cancer, with Darwinian selection of tumour cells at the expense of the host. This increased epigenetic stochasticity appears to be mediated by large-scale changes in DNA methylation and chromatin in domains associated with the nuclear lamina. The implications for diagnosis include the potential to identify stochastically disrupted progenitor cells years before cancer develops, and to target drugs to epigenetic drivers of gene expression instability rather than to mean effects per se. Twit Text FOAVip Epigenetic stochasticity, nuclear structure and cancer: the implications for medicine ????J Intern Med http://www.kidney.de/pget.php?&tw=1&pmid=24635672 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24635672 #FOAvip English Wikipedia <ref>{{Cite pmid|24635672}}</ref> Epigenetic stochasticity, nuclear structure and cancer: the implications for medicine #MMPMID24635672 Feinberg AP J Intern Med 2014[Jul]; 276 (1): 5-11 PMID24635672show ga The aim of this review is to summarize an evolution of thinking about the epigenetic basis of human cancer, from the earliest studies of altered DNA methylation in cancer to the modern comprehensive epigenomic era. Converging data from epigenetic studies of primary cancers and from experimental studies of chromatin in development and epithelial?mesenchymal transition suggest a role for epigenetic stochasticity as a driving force of cancer, with Darwinian selection of tumour cells at the expense of the host. This increased epigenetic stochasticity appears to be mediated by large-scale changes in DNA methylation and chromatin in domains associated with the nuclear lamina. The implications for diagnosis include the potential to identify stochastically disrupted progenitor cells years before cancer develops, and to target drugs to epigenetic drivers of gene expression instability rather than to mean effects per se. äEpigenetic stochasticity, nuclear structure and cancer: the implicatio(epmc).pdf DeepDyve Pubget Overpricing