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10.1093/rheumatology/keu015 http://scihub22266oqcxt.onion/10.1093/rheumatology/keu015 C4065007!4065007!24599920     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Rheumatology+(Oxford) 2014 ; 53 (7): 1301-6 Nephropedia Template TP {{tp|p=24599920|t=2014. A role for bradykinin in the development of anti-collagen antibody-induced arthritis |pdf=|usr=}}{{24599920}} gab.com Text A role for bradykinin in the development of anti-collagen antibody-induced arthritis JO: Rheumatology (Oxford) http://www.kidney.de/pget.php?&tw=1&pmid=24599920 #FOAvip Objectives. Clinical and experimental observations have suggested that bradykinin, a major activation product of the plasma kallikrein?kinin system, is involved in the pathogenesis of arthritis, but the pathogenic role of bradykinin receptors remains inconclusive. In this study we examined whether bradykinin receptors are important in the pathogenesis of anti-collagen antibody-induced arthritis (CAIA) using double receptor?deficient (B1RB2R?/?) mice.Methods. CAIA was induced in B1RB2R+/+ and B1RB2R?/? mice by injection of an anti-collagen antibody cocktail on day 0 and lipopolysaccharide on day 3. Severity of disease was evaluated by measurement of joint diameter and histological analysis. The expression of proinflammatory cytokines in joint tissue and peripheral mononuclear cells was determined by ELISA and real-time RT-PCR.Results. The absent expression of B1R and B2R mRNA in B1RB2R?/? mice was confirmed by RT-PCR. Although B1RB2R+/+ mice developed severe CAIA, the severity of the disease was significantly attenuated in B1RB2R?/? mice. In B1RB2R+/+ mice bearing CAIA, both B1R and B2R mRNA levels were increased in joint tissue and peripheral mononuclear cells. Compared with B1RB2R+/+ mice, the production of IL-1? and IL-6 in joint tissue and their mRNA expression in peripheral mononuclear cells were remarkably reduced in B1RB2R?/? mice.Conclusion. These observations provide genetic evidence that bradykinin plays an important role in the pathogenesis of CAIA. B1R, whose expression is induced in inflamed joint tissue and peripheral inflammatory cells, is important in the development of CAIA. Twit Text FOAVip A role for bradykinin in the development of anti-collagen antibody-induced arthritis ????Rheumatology (Oxford) http://www.kidney.de/pget.php?&tw=1&pmid=24599920 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24599920 #FOAvip English Wikipedia <ref>{{Cite pmid|24599920}}</ref> A role for bradykinin in the development of anti-collagen antibody-induced arthritis #MMPMID24599920 Xie Z; Dai J; Yang A; Wu Y Rheumatology (Oxford) 2014[Jul]; 53 (7): 1301-6 PMID24599920show ga Objectives. Clinical and experimental observations have suggested that bradykinin, a major activation product of the plasma kallikrein?kinin system, is involved in the pathogenesis of arthritis, but the pathogenic role of bradykinin receptors remains inconclusive. In this study we examined whether bradykinin receptors are important in the pathogenesis of anti-collagen antibody-induced arthritis (CAIA) using double receptor?deficient (B1RB2R?/?) mice.Methods. CAIA was induced in B1RB2R+/+ and B1RB2R?/? mice by injection of an anti-collagen antibody cocktail on day 0 and lipopolysaccharide on day 3. Severity of disease was evaluated by measurement of joint diameter and histological analysis. The expression of proinflammatory cytokines in joint tissue and peripheral mononuclear cells was determined by ELISA and real-time RT-PCR.Results. The absent expression of B1R and B2R mRNA in B1RB2R?/? mice was confirmed by RT-PCR. Although B1RB2R+/+ mice developed severe CAIA, the severity of the disease was significantly attenuated in B1RB2R?/? mice. In B1RB2R+/+ mice bearing CAIA, both B1R and B2R mRNA levels were increased in joint tissue and peripheral mononuclear cells. Compared with B1RB2R+/+ mice, the production of IL-1? and IL-6 in joint tissue and their mRNA expression in peripheral mononuclear cells were remarkably reduced in B1RB2R?/? mice.Conclusion. These observations provide genetic evidence that bradykinin plays an important role in the pathogenesis of CAIA. B1R, whose expression is induced in inflamed joint tissue and peripheral inflammatory cells, is important in the development of CAIA. äA role for bradykinin in the development of anti-collagen antibody-ind(epmc).pdf DeepDyve Pubget Overpricing