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10.1182/blood-2014-03-562231 http://scihub22266oqcxt.onion/10.1182/blood-2014-03-562231 C4064335!4064335 !24820310     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24820310 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Blood 2014 ; 123 (25 ): 3988-98 Nephropedia Template TP {{tp|p=24820310 |t=2014. Increased T follicular helper cells and germinal center B cells are required for cGVHD and bronchiolitis obliterans |pdf=|usr=}}{{24820310 }} gab.com Text Increased T follicular helper cells and germinal center B cells are required for cGVHD and bronchiolitis obliterans JO: Blood http://www.kidney.de/pget.php?&tw=1&pmid=24820310 #FOAvip Chronic graft-versus-host disease (cGVHD) is a leading cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation. Having shown that germinal center (GC) formation and immunoglobulin deposition are required for multiorgan system cGVHD and associated bronchiolitis obliterans syndrome (BOS) in a murine model, we hypothesized that T follicular helper (Tfh) cells are necessary for cGVHD by supporting GC formation and maintenance. We show that increased frequency of Tfh cells correlated with increased GC B cells, cGVHD, and BOS. Although administering a highly depletionary anti-CD20 monoclonal antibody (mAb) to mice with established cGVHD resulted in peripheral B-cell depletion, B cells remained in the lung, and BOS was not reversed. BOS could be treated by eliminating production of interleukin-21 (IL-21) by donor T cells or IL-21 receptor (IL-21R) signaling of donor B cells. Development of BOS was dependent upon T cells expressing the chemokine receptor CXCR5 to facilitate T-cell trafficking to secondary lymphoid organ follicles. Blocking mAbs for IL-21/IL-21R, inducible T-cell costimulator (ICOS)/ICOS ligand, and CD40L/CD40 hindered GC formation and cGVHD. These data provide novel insights into cGVHD pathogenesis, indicate a role for Tfh cells in these processes, and suggest a new line of therapy using mAbs targeting Tfh cells to reverse cGVHD. Twit Text FOAVip Increased T follicular helper cells and germinal center B cells are required for cGVHD and bronchiolitis obliterans ????Blood http://www.kidney.de/pget.php?&tw=1&pmid=24820310 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24820310 #FOAvip English Wikipedia <ref>{{Cite pmid|24820310 }}</ref> Increased T follicular helper cells and germinal center B cells are required for cGVHD and bronchiolitis obliterans #MMPMID24820310 Flynn R ; Du J ; Veenstra RG ; Reichenbach DK ; Panoskaltsis-Mortari A ; Taylor PA ; Freeman GJ ; Serody JS ; Murphy WJ ; Munn DH ; Sarantopoulos S ; Luznik L ; Maillard I ; Koreth J ; Cutler C ; Soiffer RJ ; Antin JH ; Ritz J ; Dubovsky JA ; Byrd JC ; MacDonald KP ; Hill GR ; Blazar BR Blood 2014[Jun]; 123 (25 ): 3988-98 PMID24820310 show ga Chronic graft-versus-host disease (cGVHD) is a leading cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation. Having shown that germinal center (GC) formation and immunoglobulin deposition are required for multiorgan system cGVHD and associated bronchiolitis obliterans syndrome (BOS) in a murine model, we hypothesized that T follicular helper (Tfh) cells are necessary for cGVHD by supporting GC formation and maintenance. We show that increased frequency of Tfh cells correlated with increased GC B cells, cGVHD, and BOS. Although administering a highly depletionary anti-CD20 monoclonal antibody (mAb) to mice with established cGVHD resulted in peripheral B-cell depletion, B cells remained in the lung, and BOS was not reversed. BOS could be treated by eliminating production of interleukin-21 (IL-21) by donor T cells or IL-21 receptor (IL-21R) signaling of donor B cells. Development of BOS was dependent upon T cells expressing the chemokine receptor CXCR5 to facilitate T-cell trafficking to secondary lymphoid organ follicles. Blocking mAbs for IL-21/IL-21R, inducible T-cell costimulator (ICOS)/ICOS ligand, and CD40L/CD40 hindered GC formation and cGVHD. These data provide novel insights into cGVHD pathogenesis, indicate a role for Tfh cells in these processes, and suggest a new line of therapy using mAbs targeting Tfh cells to reverse cGVHD. |Animals [MESH] |Antibodies, Monoclonal/immunology/pharmacology [MESH] |Antigens, CD20/immunology/metabolism [MESH] |B-Lymphocytes/drug effects/*immunology/metabolism [MESH] |Bronchiolitis Obliterans/genetics/*immunology/metabolism [MESH] |CD4-Positive T-Lymphocytes/immunology/metabolism [MESH] |CD40 Antigens/immunology/metabolism [MESH] |CD40 Ligand/immunology/metabolism [MESH] |Chronic Disease [MESH] |Flow Cytometry [MESH] |Germinal Center/drug effects/*immunology/metabolism [MESH] |Graft vs Host Disease/genetics/*immunology/metabolism [MESH] |Inducible T-Cell Co-Stimulator Ligand/immunology/metabolism [MESH] |Inducible T-Cell Co-Stimulator Protein/genetics/immunology/metabolism [MESH] |Interleukin-21 [MESH] |Interleukins/genetics/immunology/metabolism [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Mice, Knockout [MESH] |Microscopy, Confocal [MESH] |Receptors, CXCR5/genetics/immunology/metabolism [MESH] |Receptors, Interleukin-21/genetics/immunology/metabolism [MESH] |Syndrome [MESH]Increased T follicular helper cells and germinal center B cells are re(epmc).pdf DeepDyve Pubget Overpricing