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Synergistic antitumor effects of a TGF? inhibitor and cyclophosphamide #MMPMID25050195
Chen X; Wakefield LM; Oppenheim JJ
Oncoimmunology 2014[]; 3 (ä): ä PMID25050195show ga
In a mouse model of breast carcinoma, the combination of cyclophosphamide and transforming growth factor ?1,2,3 (TGF?1,2,3)-targeting antibody achieved superior antineoplastic effects. This novel paradigm of synergistic chemoimmunotherapy promises to improve the clinical outcome of cancer patients with micrometastases, and thus deserves further investigation.