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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Adv+Biomed+Res
2014 ; 3
(ä): 131
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The effect of Helicobacter pylori eradication on liver enzymes in patients
referring with unexplained hypertransaminasemia
#MMPMID24949302
Salehi H
; Minakari M
; Yaghoutkar A
; Tabesh E
; Salehi M
; Mirbagher L
Adv Biomed Res
2014[]; 3
(ä): 131
PMID24949302
show ga
BACKGROUND: Evidence has shown an association of Helicobacter pylori infection
with liver dysfunction and damage. We investigated if H. pylori eradication
affects liver enzymes in patients referring with unexplained
hypertransaminasemia. MATERIALS AND METHODS: Patients with mild unexplained
hypertransaminasemia accompanied with dyspepsia and confirmed H. pylori infection
were studied. Viral, metabolic, autoimmune, and drug/toxin induced hepatitis as
well as fatty liver were all ruled-out by appropriate tests. Patients received
bismuth-containing quadruple-therapy for 2 weeks. Serum levels of liver enzymes
(alanine transaminase (ALT) and aspartate transaminase (AST)) and successful
eradication (with stool antigen test) were evaluated 4 weeks after the
medication. RESULTS: A total number of 107 patients (55 males, mean age = 35.0 ±
8.4 years) were studied. Eradication was successful in 93 patients (86.9%). Serum
levels of AST (6.3 ± 19.6 IU/L, P = 0.002) and ALT (7.8 ± 24.9 IU/L, P = 0.001)
were significantly decreased after eradication. Levels of AST and ALT decreased
to normal range respectively in 46.6% and 45.7% of the cases who had baseline
levels above the normal range. CONCLUSION: This study showed a decrease in liver
enzymes after receiving eradication regimen of H. pylori, suggesting a role for
H. pylori infection in at least some of patients with mild unexplained
hypertransaminasemia. Further studies are warranted to find the underlying
mechanisms by which H. pylori infection affects the liver and clinical importance
of such effects.