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10.1007/978-3-642-17969-3_8 http://scihub22266oqcxt.onion/10.1007/978-3-642-17969-3_8 C4062991!4062991!21695641     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=21695641&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Handb+Exp+Pharmacol 2011 ; ä (204): 193-210 Nephropedia Template TP {{tp|p=21695641|t=2011. Regulation of Endothelial Barrier Function by Cyclic Nucleotides: The Role of Phosphodiesterases |pdf=|usr=}}{{21695641}} gab.com Text Regulation of Endothelial Barrier Function by Cyclic Nucleotides: The Role of Phosphodiesterases JO: Handb Exp Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=21695641 #FOAvip The endothelium plays an important role in maintaining normal vascular function. Endothelial barrier dysfunction leading to increased permeability and vascular leakage is associated with several pathological conditions such as edema and sepsis. Thus, the development of drugs that improve endothelial barrier function is an active area of research. In this chapter, the current knowledge concerning the signaling pathways regulating endothelial barrier function is discussed with a focus on cyclic nucleotide second messengers (cAMP and cGMP) and cyclic nucleotide phosphodiesterases (PDEs). Both cAMP and cGMP have been shown to have differential effects on endothelial permeability in part due to the various effector molecules, crosstalk, and compartmentalization of cyclic nucleotide signaling. PDEs, by controlling the amplitude, duration, and localization of cyclic nucleotides, have been shown to play a critical role in regulating endothelial barrier function. Thus, PDEs are attractive drug targets for the treatment of disease states involving endothelial barrier dysfunction. Twit Text FOAVip Regulation of Endothelial Barrier Function by Cyclic Nucleotides: The Role of Phosphodiesterases ????Handb Exp Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=21695641 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=21695641 #FOAvip English Wikipedia <ref>{{Cite pmid|21695641}}</ref> Regulation of Endothelial Barrier Function by Cyclic Nucleotides: The Role of Phosphodiesterases #MMPMID21695641 Surapisitchat J; Beavo JA Handb Exp Pharmacol 2011[]; ä (204): 193-210 PMID21695641show ga The endothelium plays an important role in maintaining normal vascular function. Endothelial barrier dysfunction leading to increased permeability and vascular leakage is associated with several pathological conditions such as edema and sepsis. Thus, the development of drugs that improve endothelial barrier function is an active area of research. In this chapter, the current knowledge concerning the signaling pathways regulating endothelial barrier function is discussed with a focus on cyclic nucleotide second messengers (cAMP and cGMP) and cyclic nucleotide phosphodiesterases (PDEs). Both cAMP and cGMP have been shown to have differential effects on endothelial permeability in part due to the various effector molecules, crosstalk, and compartmentalization of cyclic nucleotide signaling. PDEs, by controlling the amplitude, duration, and localization of cyclic nucleotides, have been shown to play a critical role in regulating endothelial barrier function. Thus, PDEs are attractive drug targets for the treatment of disease states involving endothelial barrier dysfunction. äRegulation of Endothelial Barrier Function by Cyclic Nucleotides: The (epmc).pdf DeepDyve Pubget Overpricing