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10.1016/j.amjcard.2011.08.010

http://scihub22266oqcxt.onion/10.1016/j.amjcard.2011.08.010
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C4062871!4062871!21962993
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suck abstract from ncbi


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pmid21962993      Am+J+Cardiol 2012 ; 109 (1): 95-9
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  • Usefulness of High-Sensitivity C-Reactive Protein to Predict Mortality in Patients with Atrial Fibrillation (From the Atherosclerosis Risk in Communities ARIC Study) #MMPMID21962993
  • Hermida J; Lopez FL; Montes R; Matsushita K; Astor BC; Alonso A
  • Am J Cardiol 2012[Jan]; 109 (1): 95-9 PMID21962993show ga
  • High-sensitivity C-reactive protein (hs-CRP) is a marker for risk of cardiovascular and overall mortality, but information about the association between hs-CRP and mortality in atrial fibrillation (AF) patients is scarce. A total of 293 participants of the Atherosclerosis Risk in Communities (ARIC) Study with a history of AF and available hs-CRP levels were studied. During a median time follow-up of 9.4 years, 134 participants died (46%). The hazard ratio (HR) of all-cause mortality associated with the highest vs. the lowest tertile of hs-CRP was 2.52; 95% CI 1.49?4.25 after adjusting for age, sex, history of cardiovascular diseases and cardiovascular risk factors. A similar trend was observed for cardiovascular mortality (57 events) (HR=1.90; 95% CI 0.81?4.45). CHADS2 score was also associated with all-cause and cardiovascular mortality: the adjusted HR were, respectively, 3.39 (95% CI 1.91?6.01) and 8.71, (95% CI 2.98?25.47) comparing those with CHADS2>2 versus CHADS2=0. Adding hs-CRP to a predictive model including CHADS2 score was associated with an improvement of the C-statistic for total mortality (from 0.627 to 0.677) and for cardiovascular mortality (from 0.700 to 0.718). In conclusion, high levels of hs-CRP constitute an independent marker for risk of mortality in AF patients.
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