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10.1016/j.amjcard.2011.08.010

http://scihub22266oqcxt.onion/10.1016/j.amjcard.2011.08.010
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suck abstract from ncbi


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pmid21962993
      Am+J+Cardiol 2012 ; 109 (1 ): 95-9
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  • Usefulness of high-sensitivity C-reactive protein to predict mortality in patients with atrial fibrillation (from the Atherosclerosis Risk In Communities ARIC Study) #MMPMID21962993
  • Hermida J ; Lopez FL ; Montes R ; Matsushita K ; Astor BC ; Alonso A
  • Am J Cardiol 2012[Jan]; 109 (1 ): 95-9 PMID21962993 show ga
  • High-sensitivity C-reactive protein (hs-CRP) is a marker for the risk of cardiovascular and overall mortality. However, information about the association between hs-CRP and mortality in patients with atrial fibrillation is scarce. A total of 293 participants of the Atherosclerosis Risk In Communities study with a history of AF and hs-CRP levels available were studied. During a median follow-up of 9.4 years, 134 participants died (46%). The hazard ratio of all-cause mortality associated with the highest versus the lowest tertile of hs-CRP was 2.52 (95% confidence interval 1.49 to 4.25) after adjusting for age, gender, history of cardiovascular diseases, and cardiovascular risk factors. A similar trend was observed for cardiovascular mortality (57 events; hazard ratio 1.90, 95% confidence interval 0.81 to 4.45). The Congestive heart failure, Hypertension, Age >75 years, Diabetes, and previous Stroke or transient ischemic attack (CHADS2) score was also associated with all-cause and cardiovascular mortality, with an adjusted hazard ratio of 3.39 (95% confidence interval 1.91 to 6.01) and 8.71 (95% confidence interval 2.98 to 25.47), respectively, comparing those with a CHADS2 score >2 versus a CHADS2 score of 0. Adding hs-CRP to a predictive model including the CHADS2 score was associated with an improvement of the C-statistic for total mortality (from 0.627 to 0.677) and for cardiovascular mortality (from 0.700 to 0.718). In conclusion, high levels of hs-CRP constitute an independent marker for the risk of mortality in patients with atrial fibrillation.
  • |Atherosclerosis/blood/complications/*epidemiology [MESH]
  • |Atrial Fibrillation/*blood/etiology/mortality [MESH]
  • |Biomarkers/blood [MESH]
  • |C-Reactive Protein/*metabolism [MESH]
  • |Cause of Death/trends [MESH]
  • |Electrocardiography [MESH]
  • |Female [MESH]
  • |Follow-Up Studies [MESH]
  • |Humans [MESH]
  • |Incidence [MESH]
  • |Male [MESH]
  • |Middle Aged [MESH]
  • |Predictive Value of Tests [MESH]
  • |Prognosis [MESH]
  • |Retrospective Studies [MESH]
  • |Risk Factors [MESH]
  • |Sex Distribution [MESH]
  • |Survival Rate/trends [MESH]


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