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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Am+J+Cardiol
2012 ; 109
(1
): 95-9
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Usefulness of high-sensitivity C-reactive protein to predict mortality in
patients with atrial fibrillation (from the Atherosclerosis Risk In Communities
ARIC Study)
#MMPMID21962993
Hermida J
; Lopez FL
; Montes R
; Matsushita K
; Astor BC
; Alonso A
Am J Cardiol
2012[Jan]; 109
(1
): 95-9
PMID21962993
show ga
High-sensitivity C-reactive protein (hs-CRP) is a marker for the risk of
cardiovascular and overall mortality. However, information about the association
between hs-CRP and mortality in patients with atrial fibrillation is scarce. A
total of 293 participants of the Atherosclerosis Risk In Communities study with a
history of AF and hs-CRP levels available were studied. During a median follow-up
of 9.4 years, 134 participants died (46%). The hazard ratio of all-cause
mortality associated with the highest versus the lowest tertile of hs-CRP was
2.52 (95% confidence interval 1.49 to 4.25) after adjusting for age, gender,
history of cardiovascular diseases, and cardiovascular risk factors. A similar
trend was observed for cardiovascular mortality (57 events; hazard ratio 1.90,
95% confidence interval 0.81 to 4.45). The Congestive heart failure,
Hypertension, Age >75 years, Diabetes, and previous Stroke or transient ischemic
attack (CHADS2) score was also associated with all-cause and cardiovascular
mortality, with an adjusted hazard ratio of 3.39 (95% confidence interval 1.91 to
6.01) and 8.71 (95% confidence interval 2.98 to 25.47), respectively, comparing
those with a CHADS2 score >2 versus a CHADS2 score of 0. Adding hs-CRP to a
predictive model including the CHADS2 score was associated with an improvement of
the C-statistic for total mortality (from 0.627 to 0.677) and for cardiovascular
mortality (from 0.700 to 0.718). In conclusion, high levels of hs-CRP constitute
an independent marker for the risk of mortality in patients with atrial
fibrillation.