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10.1158/0008-5472.CAN-11-2863 http://scihub22266oqcxt.onion/10.1158/0008-5472.CAN-11-2863 C4062074!4062074!22237629     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cancer+Res 2012 ; 72 (4): 928-38 Nephropedia Template TP {{tp|p=22237629|t=2012. Antigen-specific CD4+ T cells regulate function of myeloid-derived suppressor cells in cancer via retrograde MHC class II signaling |pdf=|usr=}}{{22237629}} gab.com Text Antigen-specific CD4+ T cells regulate function of myeloid-derived suppressor cells in cancer via retrograde MHC class II signaling JO: Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=22237629 #FOAvip Myeloid-derived suppressor cells (MDSC) play a major role in cancer-related immune suppression, yet the nature of this suppression remains controversial. In this study, we evaluated the ability of MDSC to elicit CD4+ T cell tolerance in different mouse tumor models. In contrast to CD8+ T-cell tolerance, which could be induced by MDSC in all the tumor models tested, CD4+ T-cell tolerance could be elicited in only one of the models (MC38) where a substantial level of MHC class II was expressed on MDSC, compared to control myeloid cells. Mechanistic investigations revealed that MDSC deficient in MHC class II could induce tolerance to CD8+ T cells but not to CD4+ T cells. Unexpectedly, antigen-specific CD4+ T cells (but not CD8+ T cells) could dramatically enhance the immune suppressive activity of MDSC by converting them into powerful non-specific suppressor cells. This striking effect was mediated by direct cell-cell contact through cross-linking of MHC class II on MDSC. We also implicated an Ets-1 transcription factor-regulated increase in expression of Cox-2 and prostaglandin E2 in MDSCs in mediating this effect. Together, our findings suggest that activated CD4+ T cells that are antigen-specific may enhance the immune suppressive activity of MDSC, a mechanism that might serve normally as a negative feedback loop to control immune responses that becomes dysregulated in cancer. Twit Text FOAVip Antigen-specific CD4+ T cells regulate function of myeloid-derived suppressor cells in cancer via retrograde MHC class II signaling ????Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=22237629 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=22237629 #FOAvip English Wikipedia <ref>{{Cite pmid|22237629}}</ref> Antigen-specific CD4+ T cells regulate function of myeloid-derived suppressor cells in cancer via retrograde MHC class II signaling #MMPMID22237629 Nagaraj S; Nelson A; Youn Ji; Cheng P; Quiceno D; Gabrilovich DI Cancer Res 2012[Feb]; 72 (4): 928-38 PMID22237629show ga Myeloid-derived suppressor cells (MDSC) play a major role in cancer-related immune suppression, yet the nature of this suppression remains controversial. In this study, we evaluated the ability of MDSC to elicit CD4+ T cell tolerance in different mouse tumor models. In contrast to CD8+ T-cell tolerance, which could be induced by MDSC in all the tumor models tested, CD4+ T-cell tolerance could be elicited in only one of the models (MC38) where a substantial level of MHC class II was expressed on MDSC, compared to control myeloid cells. Mechanistic investigations revealed that MDSC deficient in MHC class II could induce tolerance to CD8+ T cells but not to CD4+ T cells. Unexpectedly, antigen-specific CD4+ T cells (but not CD8+ T cells) could dramatically enhance the immune suppressive activity of MDSC by converting them into powerful non-specific suppressor cells. This striking effect was mediated by direct cell-cell contact through cross-linking of MHC class II on MDSC. We also implicated an Ets-1 transcription factor-regulated increase in expression of Cox-2 and prostaglandin E2 in MDSCs in mediating this effect. Together, our findings suggest that activated CD4+ T cells that are antigen-specific may enhance the immune suppressive activity of MDSC, a mechanism that might serve normally as a negative feedback loop to control immune responses that becomes dysregulated in cancer. äAntigen-specific CD4+ T cells regulate function of myeloid-derived sup(epmc).pdf DeepDyve Pubget Overpricing