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10.1021/tx2005234 http://scihub22266oqcxt.onion/10.1021/tx2005234 C4061765!4061765 !22263838     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=22263838 &cmd=llinks): Failed to open stream: HTTP request failed! 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Small molecule signaling agents: the integrated chemistry and biochemistry of nitrogen oxides, oxides of carbon, dioxygen, hydrogen sulfide, and their derived species |pdf=|usr=}}{{22263838 }} gab.com Text Small molecule signaling agents: the integrated chemistry and biochemistry of nitrogen oxides, oxides of carbon, dioxygen, hydrogen sulfide, and their derived species JO: Chem Res Toxicol http://www.kidney.de/pget.php?&tw=1&pmid=22263838 #FOAvip Several small molecule species formally known primarily as toxic gases have, over the past 20 years, been shown to be endogenously generated signaling molecules. The biological signaling associated with the small molecules NO, CO, H?S (and the nonendogenously generated O?), and their derived species have become a topic of extreme interest. It has become increasingly clear that these small molecule signaling agents form an integrated signaling web that affects/regulates numerous physiological processes. The chemical interactions between these species and each other or biological targets is an important factor in their roles as signaling agents. Thus, a fundamental understanding of the chemistry of these molecules is essential to understanding their biological/physiological utility. This review focuses on this chemistry and attempts to establish the chemical basis for their signaling functions. Twit Text FOAVip Small molecule signaling agents: the integrated chemistry and biochemistry of nitrogen oxides, oxides of carbon, dioxygen, hydrogen sulfide, and their derived species ????Chem Res Toxicol http://www.kidney.de/pget.php?&tw=1&pmid=22263838 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=22263838 #FOAvip English Wikipedia <ref>{{Cite pmid|22263838 }}</ref> Small molecule signaling agents: the integrated chemistry and biochemistry of nitrogen oxides, oxides of carbon, dioxygen, hydrogen sulfide, and their derived species #MMPMID22263838 Fukuto JM ; Carrington SJ ; Tantillo DJ ; Harrison JG ; Ignarro LJ ; Freeman BA ; Chen A ; Wink DA Chem Res Toxicol 2012[Apr]; 25 (4 ): 769-93 PMID22263838 show ga Several small molecule species formally known primarily as toxic gases have, over the past 20 years, been shown to be endogenously generated signaling molecules. The biological signaling associated with the small molecules NO, CO, H?S (and the nonendogenously generated O?), and their derived species have become a topic of extreme interest. It has become increasingly clear that these small molecule signaling agents form an integrated signaling web that affects/regulates numerous physiological processes. The chemical interactions between these species and each other or biological targets is an important factor in their roles as signaling agents. Thus, a fundamental understanding of the chemistry of these molecules is essential to understanding their biological/physiological utility. This review focuses on this chemistry and attempts to establish the chemical basis for their signaling functions. |*Signal Transduction [MESH] |Carbon Monoxide/chemistry [MESH] |Hydrogen Sulfide/*chemistry/metabolism [MESH] |Hypoxia-Inducible Factor 1, alpha Subunit/chemistry/metabolism [MESH] |Myoglobin/chemistry [MESH] |Nitrogen Oxides/*chemistry/metabolism [MESH] |Oxygen/*chemistry [MESH] |Reactive Nitrogen Species/chemistry [MESH]Small molecule signaling agents: the integrated chemistry and biochemi(epmc).pdf DeepDyve Pubget Overpricing