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10.1111/ejn.12556 http://scihub22266oqcxt.onion/10.1111/ejn.12556 C4061245!4061245 !24649970     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24649970 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Eur+J+Neurosci 2014 ; 39 (12 ): 2129-38 Nephropedia Template TP {{tp|p=24649970 |t=2014. Chronic metformin treatment improves post-stroke angiogenesis and recovery after experimental stroke |pdf=|usr=}}{{24649970 }} gab.com Text Chronic metformin treatment improves post-stroke angiogenesis and recovery after experimental stroke JO: Eur J Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=24649970 #FOAvip Metformin is currently the first-line treatment drug for type 2 diabetes. Metformin is a well-known activator of AMP-activated protein kinase (AMPK). In experimental studies, metformin has been shown to exert direct vascular effects by increasing vascular endothelial growth factor expression and improving microvascular density. As stroke is the leading cause of long-term disability and angiogenesis is implicated as an important mechanism in functional recovery, we hypothesized that chronic metformin treatment would improve post-stroke functional recovery by enhancing functional microvascular density. For this study, C57BL/6N male mice were subjected to a 60-min middle cerebral artery occlusion, and were given 50 mg/kg/day metformin beginning 24 h post-stroke for 3 weeks. Behavioral recovery was assessed using adhesive-tape removal and the apomorphine-induced turning test. The role of angiogenesis was assessed by counting vessel branch points from fluorescein-conjugated lectin-perfused brain sections. Importantly even if metformin treatment was initiated 24 h after injury it enhanced recovery and significantly improved stroke-induced behavioral deficits. This recovery occurred in parallel with enhanced angiogenesis and with restoration of endogenous cerebral dopaminergic tone and revascularization of ischemic tissue. We assessed if the effects on recovery and angiogenesis were mediated by AMPK. When tested in AMPK ?-2 knockout mice, we found that metformin treatment did not have the same beneficial effects on recovery and angiogenesis, suggesting that metformin-induced angiogenic effects are mediated by AMPK. The results from this study suggest that metformin mediates post-stroke recovery by enhancing angiogenesis, and these effects are mediated by AMPK signaling. Twit Text FOAVip Chronic metformin treatment improves post-stroke angiogenesis and recovery after experimental stroke ????Eur J Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=24649970 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24649970 #FOAvip English Wikipedia <ref>{{Cite pmid|24649970 }}</ref> Chronic metformin treatment improves post-stroke angiogenesis and recovery after experimental stroke #MMPMID24649970 Venna VR ; Li J ; Hammond MD ; Mancini NS ; McCullough LD Eur J Neurosci 2014[Jun]; 39 (12 ): 2129-38 PMID24649970 show ga Metformin is currently the first-line treatment drug for type 2 diabetes. Metformin is a well-known activator of AMP-activated protein kinase (AMPK). In experimental studies, metformin has been shown to exert direct vascular effects by increasing vascular endothelial growth factor expression and improving microvascular density. As stroke is the leading cause of long-term disability and angiogenesis is implicated as an important mechanism in functional recovery, we hypothesized that chronic metformin treatment would improve post-stroke functional recovery by enhancing functional microvascular density. For this study, C57BL/6N male mice were subjected to a 60-min middle cerebral artery occlusion, and were given 50 mg/kg/day metformin beginning 24 h post-stroke for 3 weeks. Behavioral recovery was assessed using adhesive-tape removal and the apomorphine-induced turning test. The role of angiogenesis was assessed by counting vessel branch points from fluorescein-conjugated lectin-perfused brain sections. Importantly even if metformin treatment was initiated 24 h after injury it enhanced recovery and significantly improved stroke-induced behavioral deficits. This recovery occurred in parallel with enhanced angiogenesis and with restoration of endogenous cerebral dopaminergic tone and revascularization of ischemic tissue. We assessed if the effects on recovery and angiogenesis were mediated by AMPK. When tested in AMPK ?-2 knockout mice, we found that metformin treatment did not have the same beneficial effects on recovery and angiogenesis, suggesting that metformin-induced angiogenic effects are mediated by AMPK. The results from this study suggest that metformin mediates post-stroke recovery by enhancing angiogenesis, and these effects are mediated by AMPK signaling. |AMP-Activated Protein Kinases/genetics/metabolism [MESH] |Animals [MESH] |Apomorphine/pharmacology [MESH] |Brain/drug effects/pathology/physiopathology [MESH] |Disease Models, Animal [MESH] |Dopamine Agonists/pharmacology [MESH] |Infarction, Middle Cerebral Artery/*drug therapy/pathology/physiopathology [MESH] |Male [MESH] |Metformin/*pharmacology [MESH] |Mice, Inbred C57BL [MESH] |Mice, Knockout [MESH] |Motor Activity/*drug effects/physiology [MESH] |Neovascularization, Pathologic/*drug therapy/pathology/physiopathology [MESH] |Neuroglia/drug effects/physiology [MESH] |Neuroprotective Agents/*pharmacology [MESH] |Physical Stimulation [MESH] |Random Allocation [MESH] |Recovery of Function/*drug effects/physiology [MESH] |Stroke [MESH]Chronic metformin treatment improves post-stroke angiogenesis and reco(epmc).pdf DeepDyve Pubget Overpricing