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10.1021/ml5001239 http://scihub22266oqcxt.onion/10.1021/ml5001239 C4060928!4060928 !24944750     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24944750 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       ACS+Med+Chem+Lett 2014 ; 5 (6 ): 717-21 Nephropedia Template TP {{tp|p=24944750 |t=2014. Discovery of MK-4409, a Novel Oxazole FAAH Inhibitor for the Treatment of Inflammatory and Neuropathic Pain |pdf=|usr=}}{{24944750 }} gab.com Text Discovery of MK-4409, a Novel Oxazole FAAH Inhibitor for the Treatment of Inflammatory and Neuropathic Pain JO: ACS Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=24944750 #FOAvip We report herein the identification of MK-4409, a potent and selective fatty acid amide hydrolase (FAAH) inhibitor. Starting from a high throughput screening (HTS) hit, medicinal chemistry efforts focused on optimizing of FAAH inhibition in vitro potency, improving the pharmacokinetic (PK) profile, and increasing in vivo efficacy in rodent inflammatory and neuropathic pain assays. Twit Text FOAVip Discovery of MK-4409, a Novel Oxazole FAAH Inhibitor for the Treatment of Inflammatory and Neuropathic Pain ????ACS Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=24944750 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24944750 #FOAvip English Wikipedia <ref>{{Cite pmid|24944750 }}</ref> Discovery of MK-4409, a Novel Oxazole FAAH Inhibitor for the Treatment of Inflammatory and Neuropathic Pain #MMPMID24944750 Chobanian HR ; Guo Y ; Liu P ; Chioda MD ; Fung S ; Lanza TJ ; Chang L ; Bakshi RK ; Dellureficio JP ; Hong Q ; McLaughlin M ; Belyk KM ; Krska SW ; Makarewicz AK ; Martel EJ ; Leone JF ; Frey L ; Karanam B ; Madeira M ; Alvaro R ; Shuman J ; Salituro G ; Terebetski JL ; Jochnowitz N ; Mistry S ; McGowan E ; Hajdu R ; Rosenbach M ; Abbadie C ; Alexander JP ; Shiao LL ; Sullivan KM ; Nargund RP ; Wyvratt MJ ; Lin LS ; DeVita RJ ACS Med Chem Lett 2014[Jun]; 5 (6 ): 717-21 PMID24944750 show ga We report herein the identification of MK-4409, a potent and selective fatty acid amide hydrolase (FAAH) inhibitor. Starting from a high throughput screening (HTS) hit, medicinal chemistry efforts focused on optimizing of FAAH inhibition in vitro potency, improving the pharmacokinetic (PK) profile, and increasing in vivo efficacy in rodent inflammatory and neuropathic pain assays. ?Discovery of MK-4409, a Novel Oxazole FAAH Inhibitor for the Treatment(epmc).pdf DeepDyve Pubget Overpricing