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New Insights into the Role of Plg-RKT in Macrophage Recruitment #MMPMID24529725
Miles LA; Lighvani S; Baik N; Khaldoyanidi S; Mueller BM; Parmer RJ
Int Rev Cell Mol Biol 2014[]; 309 (ä): 259-302 PMID24529725show ga
Plasminogen is the zymogen of plasmin, the major enzyme that degrades fibrin clots. In addition to its binding and activation on fibrin clots, plasminogen also specifically interacts with cell surfaces where it is more efficiently activated by plasminogen activators, compared with the reaction in solution. This results in association of the broad spectrum proteolytic activity of plasmin with cell surfaces that functions to promote cell migration. Here we review emerging data establishing a role for plasminogen, plasminogen receptors and the newly discovered plasminogen receptor, Plg-RKT, in macrophage recruitment in the inflammatory response and we address mechanisms by which the interplay between plasminogen and its receptors regulates inflammation.